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Page 1
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, Rosenfeld SA, Copeland RA, Decicco CP, Wynn R, Rockwell A, Yang F, Duke JL, Solomon K, George H, Bruckner R, Nagase H, Itoh Y, Ellis DM, Ross H, Wiswall BH, Murphy K, Hillman MC Jr, Hollis GF, Newton RC, Magolda RL, Trzaskos JM, Arner EC. Tortorella MD, et al. Among authors: magolda rl. Science. 1999 Jun 4;284(5420):1664-6. doi: 10.1126/science.284.5420.1664. Science. 1999. PMID: 10356395
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
Abbaszade I, Liu RQ, Yang F, Rosenfeld SA, Ross OH, Link JR, Ellis DM, Tortorella MD, Pratta MA, Hollis JM, Wynn R, Duke JL, George HJ, Hillman MC Jr, Murphy K, Wiswall BH, Copeland RA, Decicco CP, Bruckner R, Nagase H, Itoh Y, Newton RC, Magolda RL, Trzaskos JM, Burn TC, et al. Abbaszade I, et al. Among authors: magolda rl. J Biol Chem. 1999 Aug 13;274(33):23443-50. doi: 10.1074/jbc.274.33.23443. J Biol Chem. 1999. PMID: 10438522 Free article.
Aggrecan protects cartilage collagen from proteolytic cleavage.
Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC. Pratta MA, et al. J Biol Chem. 2003 Nov 14;278(46):45539-45. doi: 10.1074/jbc.M303737200. Epub 2003 Jul 30. J Biol Chem. 2003. PMID: 12890681 Free article.
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Yao W, Wasserman ZR, Chao M, Reddy G, Shi E, Liu RQ, Covington MB, Arner EC, Pratta MA, Tortorella M, Magolda RL, Newton R, Qian M, Ribadeneira MD, Christ D, Wexler RR, Decicco CP. Yao W, et al. Among authors: magolda rl. J Med Chem. 2001 Oct 11;44(21):3347-50. doi: 10.1021/jm015533c. J Med Chem. 2001. PMID: 11585439
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Xue CB, He X, Corbett RL, Roderick J, Wasserman ZR, Liu RQ, Jaffee BD, Covington MB, Qian M, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: magolda rl. J Med Chem. 2001 Oct 11;44(21):3351-4. doi: 10.1021/jm0155502. J Med Chem. 2001. PMID: 11585440
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: magolda rl. J Med Chem. 2001 Aug 2;44(16):2636-60. doi: 10.1021/jm010127e. J Med Chem. 2001. PMID: 11472217
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Cherney RJ, Mo R, Meyer DT, Wang L, Yao W, Wasserman ZR, Liu RQ, Covington MB, Tortorella MD, Arner EC, Qian M, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Decicco CP. Cherney RJ, et al. Among authors: magolda rl. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1297-300. doi: 10.1016/s0960-894x(03)00124-0. Bioorg Med Chem Lett. 2003. PMID: 12657268
71 results