van Deemter L - Search Results

1

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug.

Jonker JW, Wagenaar E, van Deemter L, Gottschlich R, Bender HM, Dasenbrock J, Schinkel AH. Jonker JW, et al. Among authors: van deemter l. Br J Pharmacol. 1999 May;127(1):43-50. doi: 10.1038/sj.bjp.0702497. Br J Pharmacol. 1999. PMID: 10369454 Free PMC article.

2

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, et al. Schinkel AH, et al. Among authors: van deemter l, van tellingen o, van der valk ma. Cell. 1994 May 20;77(4):491-502. doi: 10.1016/0092-8674(94)90212-7. Cell. 1994. PMID: 7910522

3

Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals.

Borst P, Schinkel AH, Smit JJ, Wagenaar E, Van Deemter L, Smith AJ, Eijdems EW, Baas F, Zaman GJ. Borst P, et al. Among authors: van deemter l. Pharmacol Ther. 1993 Nov;60(2):289-99. doi: 10.1016/0163-7258(93)90011-2. Pharmacol Ther. 1993. PMID: 7912835 Review.

4

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Schinkel AH, Wagenaar E, Mol CA, van Deemter L. Schinkel AH, et al. Among authors: van deemter l. J Clin Invest. 1996 Jun 1;97(11):2517-24. doi: 10.1172/JCI118699. J Clin Invest. 1996. PMID: 8647944 Free PMC article.

5

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

Allen JD, Brinkhuis RF, van Deemter L, Wijnholds J, Schinkel AH. Allen JD, et al. Among authors: van deemter l. Cancer Res. 2000 Oct 15;60(20):5761-6. Cancer Res. 2000. PMID: 11059771

6

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Schinkel AH, Wagenaar E, van Deemter L, Mol CA, Borst P. Schinkel AH, et al. Among authors: van deemter l. J Clin Invest. 1995 Oct;96(4):1698-705. doi: 10.1172/JCI118214. J Clin Invest. 1995. PMID: 7560060 Free PMC article.

7

Multidrug resistance and the role of P-glycoprotein knockout mice.

Schinkel AH, Mol CA, Wagenaar E, van Deemter L, Smit JJ, Borst P. Schinkel AH, et al. Among authors: van deemter l. Eur J Cancer. 1995 Jul-Aug;31A(7-8):1295-8. doi: 10.1016/0959-8049(95)00130-b. Eur J Cancer. 1995. PMID: 7577039 Review.

8

Characterization of the promoter region of the human MDR3 P-glycoprotein gene.

Smit JJ, Mol CA, van Deemter L, Wagenaar E, Schinkel AH, Borst P. Smit JJ, et al. Among authors: van deemter l. Biochim Biophys Acta. 1995 Mar 14;1261(1):44-56. doi: 10.1016/0167-4781(94)00214-n. Biochim Biophys Acta. 1995. PMID: 7893760

9

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease.

Smit JJ, Schinkel AH, Oude Elferink RP, Groen AK, Wagenaar E, van Deemter L, Mol CA, Ottenhoff R, van der Lugt NM, van Roon MA, et al. Smit JJ, et al. Among authors: van roon ma, van deemter l, van der lugt nm. Cell. 1993 Nov 5;75(3):451-62. doi: 10.1016/0092-8674(93)90380-9. Cell. 1993. PMID: 8106172

10

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

Evers R, Zaman GJ, van Deemter L, Jansen H, Calafat J, Oomen LC, Oude Elferink RP, Borst P, Schinkel AH. Evers R, et al. Among authors: van deemter l. J Clin Invest. 1996 Mar 1;97(5):1211-8. doi: 10.1172/JCI118535. J Clin Invest. 1996. PMID: 8636432 Free PMC article.

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