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Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
Nishina H, Bachmann M, Oliveira-dos-Santos AJ, Kozieradzki I, Fischer KD, Odermatt B, Wakeham A, Shahinian A, Takimoto H, Bernstein A, Mak TW, Woodgett JR, Ohashi PS, Penninger JM. Nishina H, et al. Among authors: fischer kd. J Exp Med. 1997 Sep 15;186(6):941-53. doi: 10.1084/jem.186.6.941. J Exp Med. 1997. PMID: 9294148 Free PMC article.
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.
Fischer KD, Kong YY, Nishina H, Tedford K, Marengère LE, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM. Fischer KD, et al. Curr Biol. 1998 May 7;8(10):554-62. doi: 10.1016/s0960-9822(98)70224-6. Curr Biol. 1998. PMID: 9601639 Free article.
Vav regulates peptide-specific apoptosis in thymocytes.
Kong YY, Fischer KD, Bachmann MF, Mariathasan S, Kozieradzki I, Nghiem MP, Bouchard D, Bernstein A, Ohashi PS, Penninger JM. Kong YY, et al. Among authors: fischer kd. J Exp Med. 1998 Dec 7;188(11):2099-111. doi: 10.1084/jem.188.11.2099. J Exp Med. 1998. PMID: 9841924 Free PMC article.
The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation.
Penninger JM, Fischer KD, Sasaki T, Kozieradzki I, Le J, Tedford K, Bachmaier K, Ohashi PS, Bachmann MF. Penninger JM, et al. Among authors: fischer kd. Eur J Immunol. 1999 May;29(5):1709-18. doi: 10.1002/(SICI)1521-4141(199905)29:05<1709::AID-IMMU1709>3.0.CO;2-O. Eur J Immunol. 1999. PMID: 10359126 Free article.
Vav-1 regulates NK T cell development and NK cell cytotoxicity.
Chan G, Hanke T, Fischer KD. Chan G, et al. Among authors: fischer kd. Eur J Immunol. 2001 Aug;31(8):2403-10. doi: 10.1002/1521-4141(200108)31:8<2403::aid-immu2403>3.0.co;2-o. Eur J Immunol. 2001. PMID: 11500824 Free article.
124 results