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Page 1
Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.
Taveras AG, Deskus J, Chao J, Vaccaro CJ, Njoroge FG, Vibulbhan B, Pinto P, Remiszewski S, del Rosario J, Doll RJ, Alvarez C, Lalwani T, Mallams AK, Rossman RR, Afonso A, Girijavallabhan VM, Ganguly AK, Pramanik B, Heimark L, Bishop WR, Wang L, Kirschmeier P, James L, Carr D, Liu M, et al. Taveras AG, et al. Among authors: afonso a. J Med Chem. 1999 Jul 15;42(14):2651-61. doi: 10.1021/jm990059k. J Med Chem. 1999. PMID: 10411485
(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.
Njoroge FG, Taveras AG, Kelly J, Remiszewski S, Mallams AK, Wolin R, Afonso A, Cooper AB, Rane DF, Liu YT, Wong J, Vibulbhan B, Pinto P, Deskus J, Alvarez CS, del Rosario J, Connolly M, Wang J, Desai J, Rossman RR, Bishop WR, Patton R, Wang L, Kirschmeier P, Ganguly AK, et al. Njoroge FG, et al. Among authors: afonso a. J Med Chem. 1998 Nov 19;41(24):4890-902. doi: 10.1021/jm980462b. J Med Chem. 1998. PMID: 9822558
Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system.
Wolin R, Connolly M, Kelly J, Weinstein J, Rosenblum S, Afonso A, James L, Kirschmeier P, Bishop WR. Wolin R, et al. Among authors: afonso a. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2521-6. doi: 10.1016/s0960-894x(98)00439-9. Bioorg Med Chem Lett. 1998. PMID: 9873573
Synthesis and antibacterial activity of 2-alkoxy penems.
Afonso A, Hon F, Fett N, Weinstein J, Ganguly AK, Naples L, Hare RS, Miller GH. Afonso A, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2793-6. doi: 10.1016/s0960-894x(98)00502-2. Bioorg Med Chem Lett. 1998. PMID: 9873624
Novel H3 receptor antagonists. Sulfonamide homologs of histamine.
Wolin R, Connolly M, Afonso A, Hey JA, She H, Rivelli MA, Willams SM, West RE Jr. Wolin R, et al. Among authors: afonso a. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2157-62. doi: 10.1016/s0960-894x(98)00379-5. Bioorg Med Chem Lett. 1998. PMID: 9873505
515 results