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Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.
Taveras AG, Deskus J, Chao J, Vaccaro CJ, Njoroge FG, Vibulbhan B, Pinto P, Remiszewski S, del Rosario J, Doll RJ, Alvarez C, Lalwani T, Mallams AK, Rossman RR, Afonso A, Girijavallabhan VM, Ganguly AK, Pramanik B, Heimark L, Bishop WR, Wang L, Kirschmeier P, James L, Carr D, Liu M, et al. Taveras AG, et al. Among authors: bishop wr. J Med Chem. 1999 Jul 15;42(14):2651-61. doi: 10.1021/jm990059k. J Med Chem. 1999. PMID: 10411485
Discovery of C-imidazole azaheptapyridine FPT inhibitors.
Zhu HY, Cooper AB, Desai J, Njoroge G, Kirschmeier P, Bishop WR, Strickland C, Hruza A, Doll RJ, Girijavallabhan VM. Zhu HY, et al. Among authors: bishop wr. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1134-6. doi: 10.1016/j.bmcl.2009.12.013. Epub 2009 Dec 6. Bioorg Med Chem Lett. 2010. PMID: 20056542
Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation.
Mallams AK, Njoroge FG, Doll RJ, Snow ME, Kaminski JJ, Rossman RR, Vibulbhan B, Bishop WR, Kirschmeier P, Liu M, Bryant MS, Alvarez C, Carr D, James L, King I, Li Z, Lin CC, Nardo C, Petrin J, Remiszewski SW, Taveras AG, Wang S, Wong J, Catino J, Ganguly AK, et al. Mallams AK, et al. Among authors: bishop wr. Bioorg Med Chem. 1997 Jan;5(1):93-9. doi: 10.1016/s0968-0896(96)00205-2. Bioorg Med Chem. 1997. PMID: 9043661
83 results