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Page 1
Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.
Taveras AG, Deskus J, Chao J, Vaccaro CJ, Njoroge FG, Vibulbhan B, Pinto P, Remiszewski S, del Rosario J, Doll RJ, Alvarez C, Lalwani T, Mallams AK, Rossman RR, Afonso A, Girijavallabhan VM, Ganguly AK, Pramanik B, Heimark L, Bishop WR, Wang L, Kirschmeier P, James L, Carr D, Liu M, et al. Taveras AG, et al. Among authors: james l. J Med Chem. 1999 Jul 15;42(14):2651-61. doi: 10.1021/jm990059k. J Med Chem. 1999. PMID: 10411485
Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.
Taveras AG, Aki C, Chao J, Doll RJ, Lalwani T, Girijavallabhan V, Strickland CL, Windsor WT, Weber P, Hollinger F, Snow M, Patton R, Kirschmeier P, James L, Liu M, Nomeir A. Taveras AG, et al. Among authors: james l. J Med Chem. 2002 Aug 29;45(18):3854-64. doi: 10.1021/jm010463v. J Med Chem. 2002. PMID: 12190309
Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation.
Mallams AK, Njoroge FG, Doll RJ, Snow ME, Kaminski JJ, Rossman RR, Vibulbhan B, Bishop WR, Kirschmeier P, Liu M, Bryant MS, Alvarez C, Carr D, James L, King I, Li Z, Lin CC, Nardo C, Petrin J, Remiszewski SW, Taveras AG, Wang S, Wong J, Catino J, Ganguly AK, et al. Mallams AK, et al. Among authors: james l. Bioorg Med Chem. 1997 Jan;5(1):93-9. doi: 10.1016/s0968-0896(96)00205-2. Bioorg Med Chem. 1997. PMID: 9043661
Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex.
Taveras AG, Remiszewski SW, Doll RJ, Cesarz D, Huang EC, Kirschmeier P, Pramanik BN, Snow ME, Wang YS, del Rosario JD, Vibulbhan B, Bauer BB, Brown JE, Carr D, Catino J, Evans CA, Girijavallabhan V, Heimark L, James L, Liberles S, Nash C, Perkins L, Senior MM, Tsarbopoulos A, Webber SE, et al. Taveras AG, et al. Among authors: james l. Bioorg Med Chem. 1997 Jan;5(1):125-33. doi: 10.1016/s0968-0896(96)00202-7. Bioorg Med Chem. 1997. PMID: 9043664
Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I.
Zhang FL, Kirschmeier P, Carr D, James L, Bond RW, Wang L, Patton R, Windsor WT, Syto R, Zhang R, Bishop WR. Zhang FL, et al. Among authors: james l. J Biol Chem. 1997 Apr 11;272(15):10232-9. doi: 10.1074/jbc.272.15.10232. J Biol Chem. 1997. PMID: 9092572 Free article.
Recently, it was reported that Ki-Ras4B is also an in vitro substrate for the related enzyme geranylgeranyl protein transferase-1 (GGPT-1) (James, G. L., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 6221-6226). ...
Recently, it was reported that Ki-Ras4B is also an in vitro substrate for the related enzyme geranylgeranyl protein transferase-1 (GGPT-1) ( …
Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry.
Ganguly AK, Pramanik BN, Huang EC, Liberles S, Heimark L, Liu YH, Tsarbopoulos A, Doll RJ, Taveras AG, Remiszewski S, Snow ME, Wang YS, Vibulbhan B, Cesarz D, Brown JE, del Rosario J, James L, Kirschmeier P, Girijavallabhan V. Ganguly AK, et al. Among authors: james l. Bioorg Med Chem. 1997 May;5(5):817-20. doi: 10.1016/s0968-0896(97)00021-7. Bioorg Med Chem. 1997. PMID: 9208093
Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system.
Wolin R, Connolly M, Kelly J, Weinstein J, Rosenblum S, Afonso A, James L, Kirschmeier P, Bishop WR. Wolin R, et al. Among authors: james l. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2521-6. doi: 10.1016/s0960-894x(98)00439-9. Bioorg Med Chem Lett. 1998. PMID: 9873573
2,005 results