Leader H - Search Results

1

Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.

Luo C, Saxena A, Ashani Y, Leader H, Radić Z, Taylor P, Doctor BP. Luo C, et al. Among authors: leader h. Chem Biol Interact. 1999 May 14;119-120:129-35. doi: 10.1016/s0009-2797(99)00021-6. Chem Biol Interact. 1999. PMID: 10421446 Review.

2

Formation of an unstable covalent intermediate during the inhibition of electric-eel acetylcholinesterase with 1,3,2-dioxaphosphorinane 2-oxides.

Ashani Y, Leader H. Ashani Y, et al. Among authors: leader h. Biochem J. 1979 Mar 1;177(3):781-90. doi: 10.1042/bj1770781. Biochem J. 1979. PMID: 444203 Free PMC article.

3

Sugar-oximes, new potential antidotes against organophosphorus poisoning.

Rachaman ES, Ashani Y, Leader H, Granoth I, Edery H, Porath G. Rachaman ES, et al. Among authors: leader h. Arzneimittelforschung. 1979;29(6):875-6. doi: 10.1002/chin.197938312. Arzneimittelforschung. 1979. PMID: 582776

4

Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.

Leader H, Smejkal RM, Payne CS, Padilla FN, Doctor BP, Gordon RK, Chiang PK. Leader H, et al. J Med Chem. 1989 Jul;32(7):1522-8. doi: 10.1021/jm00127a020. J Med Chem. 1989. PMID: 2738887

5

In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.

Ashani Y, Leader H, Raveh L, Bruckstein R, Spiegelstein M. Ashani Y, et al. Among authors: leader h. J Med Chem. 1983 Feb;26(2):145-52. doi: 10.1021/jm00356a006. J Med Chem. 1983. PMID: 6827532

6

Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates.

Ashani Y, Leader H, Rothschild N, Dosoretz C. Ashani Y, et al. Among authors: leader h. Biochem Pharmacol. 1998 Jan 15;55(2):159-68. doi: 10.1016/s0006-2952(97)00430-9. Biochem Pharmacol. 1998. PMID: 9448738

7

Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases.

Leader H, Vincze A, Manisterski B, Rothschild N, Dosoretz C, Ashani Y. Leader H, et al. Biochem Pharmacol. 1999 Aug 1;58(3):503-15. doi: 10.1016/s0006-2952(99)00117-3. Biochem Pharmacol. 1999. PMID: 10424771

8

Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.

Ashani Y, Bhattacharjee AK, Leader H, Saxena A, Doctor BP. Ashani Y, et al. Among authors: leader h. Biochem Pharmacol. 2003 Jul 15;66(2):191-202. doi: 10.1016/s0006-2952(03)00204-1. Biochem Pharmacol. 2003. PMID: 12826262

9

Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.

Luo C, Leader H, Radic Z, Maxwell DM, Taylor P, Doctor BP, Saxena A. Luo C, et al. Among authors: leader h. Biochem Pharmacol. 2003 Aug 1;66(3):387-92. doi: 10.1016/s0006-2952(03)00237-5. Biochem Pharmacol. 2003. PMID: 12907237

10

Pro-2-PAM therapy for central and peripheral cholinesterases.

Demar JC, Clarkson ED, Ratcliffe RH, Campbell AJ, Thangavelu SG, Herdman CA, Leader H, Schulz SM, Marek E, Medynets MA, Ku TC, Evans SA, Khan FA, Owens RR, Nambiar MP, Gordon RK. Demar JC, et al. Among authors: leader h. Chem Biol Interact. 2010 Sep 6;187(1-3):191-8. doi: 10.1016/j.cbi.2010.02.015. Epub 2010 Feb 13. Chem Biol Interact. 2010. PMID: 20156430 Free PMC article.

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