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The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease.
Bodzioch M, Orsó E, Klucken J, Langmann T, Böttcher A, Diederich W, Drobnik W, Barlage S, Büchler C, Porsch-Ozcürümez M, Kaminski WE, Hahmann HW, Oette K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G. Bodzioch M, et al. Among authors: diederich w. Nat Genet. 1999 Aug;22(4):347-51. doi: 10.1038/11914. Nat Genet. 1999. PMID: 10431237
ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.
Klucken J, Büchler C, Orsó E, Kaminski WE, Porsch-Ozcürümez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Schmitz G. Klucken J, et al. Among authors: diederich w. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):817-22. doi: 10.1073/pnas.97.2.817. Proc Natl Acad Sci U S A. 2000. PMID: 10639163 Free PMC article.
Development of improved PPARβ/δ inhibitors.
Toth PM, Naruhn S, Pape VF, Dörr SM, Klebe G, Müller R, Diederich WE. Toth PM, et al. ChemMedChem. 2012 Jan 2;7(1):159-70. doi: 10.1002/cmdc.201100408. Epub 2011 Oct 24. ChemMedChem. 2012. PMID: 22025402
Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.
Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, Finkernagel F, Obert J, Lieber S, Scharfe M, Jarek M, Toth PM, Scheer F, Diederich WE, Reinartz S, Grosse R, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: diederich we. Oncogene. 2013 Oct 31;32(44):5241-52. doi: 10.1038/onc.2012.549. Epub 2012 Dec 3. Oncogene. 2013. PMID: 23208498 Free PMC article.
59 results