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Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state.
Abraldes JG, Iwakiri Y, Loureiro-Silva M, Haq O, Sessa WC, Groszmann RJ. Abraldes JG, et al. Among authors: groszmann rj. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G980-7. doi: 10.1152/ajpgi.00336.2005. Am J Physiol Gastrointest Liver Physiol. 2006. PMID: 16603731 Free article.
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