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1,4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats.
Napoli C, Salomone S, Godfraind T, Palinski W, Capuzzi DM, Palumbo G, D'Armiento FP, Donzelli R, de Nigris F, Capizzi RL, Mancini M, Gonnella JS, Bianchi A. Napoli C, et al. Stroke. 1999 Sep;30(9):1907-15. doi: 10.1161/01.str.30.9.1907. Stroke. 1999. PMID: 10471444
Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice.
Napoli C, Ackah E, De Nigris F, Del Soldato P, D'Armiento FP, Crimi E, Condorelli M, Sessa WC. Napoli C, et al. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12467-70. doi: 10.1073/pnas.192244499. Epub 2002 Sep 3. Proc Natl Acad Sci U S A. 2002. PMID: 12209007 Free PMC article.
Chronic treatment with sulfhydryl angiotensin-converting enzyme inhibitors reduce susceptibility of plasma LDL to in vitro oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice.
de Nigris F, D'Armiento FP, Somma P, Casini A, Andreini I, Sarlo F, Mansueto G, De Rosa G, Bonaduce D, Condorelli M, Napoli C. de Nigris F, et al. Int J Cardiol. 2001 Dec;81(2-3):107-15; discusssion 115-6. doi: 10.1016/s0167-5273(01)00542-3. Int J Cardiol. 2001. PMID: 11744122
Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.
Napoli C, D'Armiento FP, Mancini FP, Postiglione A, Witztum JL, Palumbo G, Palinski W. Napoli C, et al. J Clin Invest. 1997 Dec 1;100(11):2680-90. doi: 10.1172/JCI119813. J Clin Invest. 1997. PMID: 9389731 Free PMC article.
142 results