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Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors.
Rafi I, Boddy AV, Calvete JA, Taylor GA, Newell DR, Bailey NP, Lind MJ, Green M, Hines J, Johnstone A, Clendeninn N, Calvert AH. Rafi I, et al. Among authors: calvete ja. J Clin Oncol. 1998 Mar;16(3):1131-41. doi: 10.1200/JCO.1998.16.3.1131. J Clin Oncol. 1998. PMID: 9508200 Clinical Trial.
Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion.
Rafi I, Taylor GA, Calvete JA, Boddy AV, Balmanno K, Bailey N, Lind M, Calvert AH, Webber S, Jackson RC, et al. Rafi I, et al. Among authors: calvete ja. Clin Cancer Res. 1995 Nov;1(11):1275-84. Clin Cancer Res. 1995. PMID: 9815922 Clinical Trial.