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Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors.
Rafi I, Boddy AV, Calvete JA, Taylor GA, Newell DR, Bailey NP, Lind MJ, Green M, Hines J, Johnstone A, Clendeninn N, Calvert AH. Rafi I, et al. Among authors: taylor ga. J Clin Oncol. 1998 Mar;16(3):1131-41. doi: 10.1200/JCO.1998.16.3.1131. J Clin Oncol. 1998. PMID: 9508200 Clinical Trial.
Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion.
Rafi I, Taylor GA, Calvete JA, Boddy AV, Balmanno K, Bailey N, Lind M, Calvert AH, Webber S, Jackson RC, et al. Rafi I, et al. Among authors: taylor ga. Clin Cancer Res. 1995 Nov;1(11):1275-84. Clin Cancer Res. 1995. PMID: 9815922 Clinical Trial.
Thymidylate synthase: a target for anticancer drug design.
Harrap KR, Jackman AL, Newell DR, Taylor GA, Hughes LR, Calvert AH. Harrap KR, et al. Among authors: taylor ga. Adv Enzyme Regul. 1989;29:161-79. doi: 10.1016/0065-2571(89)90099-x. Adv Enzyme Regul. 1989. PMID: 2633608
A phase I study of nolatrexed dihydrochloride in children with advanced cancer. A United Kingdom Children's Cancer Study Group Investigation.
Estlin EJ, Pinkerton CR, Lewis IJ, Lashford L, McDowell H, Morland B, Kohler J, Newell DR, Boddy AV, Taylor GA, Price L, Ablett S, Hobson R, Pitsiladis M, Brampton M, Clendeninn N, Johnston A, Pearson AD. Estlin EJ, et al. Among authors: taylor ga. Br J Cancer. 2001 Jan 5;84(1):11-8. doi: 10.1054/bjoc.2000.1569. Br J Cancer. 2001. PMID: 11139306 Free PMC article. Clinical Trial.
545 results