De Clercq E - Search Results

1

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.

Siddiqui AQ, McGuigan C, Ballatore C, Zuccotto F, Gilbert IH, De Clercq E, Balzarini J. Siddiqui AQ, et al. Among authors: de clercq e. J Med Chem. 1999 Oct 7;42(20):4122-8. doi: 10.1021/jm9807104. J Med Chem. 1999. PMID: 10514282

2

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

McGuigan C, Cahard D, Sheeka HM, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: de clercq e. J Med Chem. 1996 Apr 12;39(8):1748-53. doi: 10.1021/jm950605j. J Med Chem. 1996. PMID: 8648614

3

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

McGuigan C, Tsang HW, Cahard D, Turner K, Velazquez S, Salgado A, Bidois L, Naesens L, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: de clercq e. Antiviral Res. 1997 Aug;35(3):195-204. doi: 10.1016/s0166-3542(97)00029-6. Antiviral Res. 1997. PMID: 9298759

4

Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).

McGuigan C, Sutton PW, Cahard D, Turner K, O'Leary G, Wang Y, Gumbleton M, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: de clercq e. Antivir Chem Chemother. 1998 Nov;9(6):473-9. doi: 10.1177/095632029800900603. Antivir Chem Chemother. 1998. PMID: 9865385

5

Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.

McGuigan C, Cahard D, Ballatore C, Siddiqui A, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: de clercq e. Bioorg Med Chem Lett. 1998 Nov 3;8(21):2949-54. doi: 10.1016/S0960-894X(98)00530-7. Bioorg Med Chem Lett. 1998. PMID: 9873653

6

Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency.

McGuigan C, Tsang HW, Sutton PW, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: de clercq e. Antivir Chem Chemother. 1998 Mar;9(2):109-15. doi: 10.1177/095632029800900202. Antivir Chem Chemother. 1998. PMID: 9875382

7

The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.

Siddiqui AQ, Ballatore C, McGuigan C, De Clercq E, Balzarini J. Siddiqui AQ, et al. Among authors: de clercq e. J Med Chem. 1999 Feb 11;42(3):393-9. doi: 10.1021/jm9803931. J Med Chem. 1999. PMID: 9986709

8

An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs.

Ballatore C, McGuigan C, De Clercq E, Balzarini J. Ballatore C, et al. Among authors: de clercq e. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):967-9. doi: 10.1080/15257779908041615. Nucleosides Nucleotides. 1999. PMID: 10432721

9

Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.

Siddiqui AQ, McGuigan C, Ballatore C, Wedgwood O, De Clercq E, Balzarini J. Siddiqui AQ, et al. Among authors: de clercq e. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2555-60. doi: 10.1016/s0960-894x(99)00416-3. Bioorg Med Chem Lett. 1999. PMID: 10498207

10

Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.

McGuigan C, Yarnold CJ, Jones G, Velázquez S, Barucki H, Brancale A, Andrei G, Snoeck R, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: de clercq e. J Med Chem. 1999 Nov 4;42(22):4479-84. doi: 10.1021/jm990346o. J Med Chem. 1999. PMID: 10579812

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