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Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors.
Kaltenbach RF 3rd, Patel M, Waltermire RE, Harris GD, Stone BR, Klabe RM, Garber S, Bacheler LT, Cordova BC, Logue K, Wright MR, Erickson-Viitanen S, Trainor GL. Kaltenbach RF 3rd, et al. Among authors: trainor gl. Bioorg Med Chem Lett. 2003 Feb 24;13(4):605-8. doi: 10.1016/s0960-894x(02)01064-8. Bioorg Med Chem Lett. 2003. PMID: 12639540
Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1.
Corbett JW, Ko SS, Rodgers JD, Jeffrey S, Bacheler LT, Klabe RM, Diamond S, Lai CM, Rabel SR, Saye JA, Adams SP, Trainor GL, Anderson PS, Erickson-Viitanen SK. Corbett JW, et al. Among authors: trainor gl. Antimicrob Agents Chemother. 1999 Dec;43(12):2893-7. doi: 10.1128/AAC.43.12.2893. Antimicrob Agents Chemother. 1999. PMID: 10582878 Free PMC article.
Identification of selective inhibitors of cyclin dependent kinase 4.
Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM. Carini DJ, et al. Among authors: trainor gl. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2209-11. doi: 10.1016/s0960-894x(01)00416-4. Bioorg Med Chem Lett. 2001. PMID: 11514172
Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.
De Lucca GV, Kim UT, Liang J, Cordova B, Klabe RM, Garber S, Bacheler LT, Lam GN, Wright MR, Logue KA, Erickson-Viitanen S, Ko SS, Trainor GL. De Lucca GV, et al. Among authors: trainor gl. J Med Chem. 1998 Jun 18;41(13):2411-23. doi: 10.1021/jm980103g. J Med Chem. 1998. PMID: 9632373
86 results