Sparrow JR - Search Results

1

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

Sparrow JR, Parish CA, Hashimoto M, Nakanishi K. Sparrow JR, et al. Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2988-95. Invest Ophthalmol Vis Sci. 1999. PMID: 10549662

2

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium.

Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow J. Parish CA, et al. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14609-13. doi: 10.1073/pnas.95.25.14609. Proc Natl Acad Sci U S A. 1998. PMID: 9843937 Free PMC article.

3

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

Sparrow JR, Nakanishi K, Parish CA. Sparrow JR, et al. Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1981-9. Invest Ophthalmol Vis Sci. 2000. PMID: 10845625

4

The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane.

Liu J, Itagaki Y, Ben-Shabat S, Nakanishi K, Sparrow JR. Liu J, et al. Among authors: sparrow jr. J Biol Chem. 2000 Sep 22;275(38):29354-60. doi: 10.1074/jbc.M910191199. J Biol Chem. 2000. PMID: 10887199 Free article.

5

Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2.

Sparrow JR, Cai B. Sparrow JR, et al. Invest Ophthalmol Vis Sci. 2001 May;42(6):1356-62. Invest Ophthalmol Vis Sci. 2001. PMID: 11328751

6

Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration.

Ben-Shabat S, Parish CA, Hashimoto M, Liu J, Nakanishi K, Sparrow JR. Ben-Shabat S, et al. Among authors: sparrow jr. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1533-40. doi: 10.1016/s0960-894x(01)00314-6. Bioorg Med Chem Lett. 2001. PMID: 11412975 Review.

7

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.

Ben-Shabat S, Parish CA, Vollmer HR, Itagaki Y, Fishkin N, Nakanishi K, Sparrow JR. Ben-Shabat S, et al. Among authors: sparrow jr. J Biol Chem. 2002 Mar 1;277(9):7183-90. doi: 10.1074/jbc.M108981200. Epub 2001 Dec 26. J Biol Chem. 2002. PMID: 11756445 Free article.

8

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

Sparrow JR, Zhou J, Ben-Shabat S, Vollmer H, Itagaki Y, Nakanishi K. Sparrow JR, et al. Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1222-7. Invest Ophthalmol Vis Sci. 2002. PMID: 11923269

9

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement.

Ben-Shabat S, Itagaki Y, Jockusch S, Sparrow JR, Turro NJ, Nakanishi K. Ben-Shabat S, et al. Among authors: sparrow jr. Angew Chem Int Ed Engl. 2002 Mar 1;41(5):814-7. doi: 10.1002/1521-3773(20020301)41:5<814::aid-anie814>3.0.co;2-2. Angew Chem Int Ed Engl. 2002. PMID: 12491345 No abstract available.

10

A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation.

Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang YP, Jockusch S, Itagaki Y, Nakanishi K. Sparrow JR, et al. J Biol Chem. 2003 May 16;278(20):18207-13. doi: 10.1074/jbc.M300457200. Epub 2003 Mar 19. J Biol Chem. 2003. PMID: 12646558 Free article.

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