O'Rahilly S - Search Results

1

The alpha-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs.

Ursø B, Brown RA, O'Rahilly S, Shepherd PR, Siddle K. Ursø B, et al. FEBS Lett. 1999 Nov 5;460(3):423-6. doi: 10.1016/s0014-5793(99)01388-5. FEBS Lett. 1999. PMID: 10556509 Free article.

2

Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes.

Ursø B, Cope DL, Kalloo-Hosein HE, Hayward AC, Whitehead JP, O'Rahilly S, Siddle K. Ursø B, et al. J Biol Chem. 1999 Oct 22;274(43):30864-73. doi: 10.1074/jbc.274.43.30864. J Biol Chem. 1999. PMID: 10521479 Free article.

3

Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes.

Ursø B, Niesler CU, O'Rahilly S, Siddle K. Ursø B, et al. Cell Signal. 2001 Apr;13(4):279-85. doi: 10.1016/s0898-6568(01)00130-9. Cell Signal. 2001. PMID: 11306245

4

Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.

Soos MA, Jensen J, Brown RA, O'Rahilly S, Shepherd PR, Whitehead JP. Soos MA, et al. Arch Biochem Biophys. 2001 Dec 15;396(2):244-8. doi: 10.1006/abbi.2001.2587. Arch Biochem Biophys. 2001. PMID: 11747303

5

Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.

Baynes KC, Beeton CA, Panayotou G, Stein R, Soos M, Hansen T, Simpson H, O'Rahilly S, Shepherd PR, Whitehead JP. Baynes KC, et al. Diabetologia. 2000 Mar;43(3):321-31. doi: 10.1007/s001250050050. Diabetologia. 2000. PMID: 10768093

6

Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1.

Mulligan C, Rochford J, Denyer G, Stephens R, Yeo G, Freeman T, Siddle K, O'Rahilly S. Mulligan C, et al. J Biol Chem. 2002 Nov 8;277(45):42480-7. doi: 10.1074/jbc.M206206200. Epub 2002 Sep 3. J Biol Chem. 2002. PMID: 12213819 Free article.

7

Functional activation of mutant human insulin receptor by monoclonal antibody.

Krook A, Soos MA, Kumar S, Siddle K, O'Rahilly S. Krook A, et al. Lancet. 1996 Jun 8;347(9015):1586-90. doi: 10.1016/s0140-6736(96)91076-4. Lancet. 1996. PMID: 8667867

8

Differential signaling to glycogen synthesis by the intracellular domain of the insulin versus the insulin-like growth factor-1 receptor. Evidence from studies of TrkC-chimeras.

Kalloo-Hosein HE, Whitehead JP, Soos M, Tavaré JM, Siddle K, O'Rahilly S. Kalloo-Hosein HE, et al. J Biol Chem. 1997 Sep 26;272(39):24325-32. doi: 10.1074/jbc.272.39.24325. J Biol Chem. 1997. PMID: 9305889 Free article.

9

Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.

Krook A, Whitehead JP, Dobson SP, Griffiths MR, Ouwens M, Baker C, Hayward AC, Sen SK, Maassen JA, Siddle K, Tavaré JM, O'Rahilly S. Krook A, et al. J Biol Chem. 1997 Nov 28;272(48):30208-14. doi: 10.1074/jbc.272.48.30208. J Biol Chem. 1997. PMID: 9374504 Free article.

10

Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance: detection and functional analysis of a naturally occurring mutation in a YMXM motif.

Whitehead JP, Humphreys P, Krook A, Jackson R, Hayward A, Lewis H, Siddle K, O'Rahilly S. Whitehead JP, et al. Diabetes. 1998 May;47(5):837-9. doi: 10.2337/diabetes.47.5.837. Diabetes. 1998. PMID: 9588458 No abstract available.

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