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Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors.
Herben VM, van Gijn R, Schellens JH, Schot M, Lieverst J, Hillebrand MJ, Schoemaker NE, Porro MG, Beijnen JH, ten Bokkel Huinink WW. Herben VM, et al. Among authors: hillebrand mj. J Clin Oncol. 1999 Jun;17(6):1906-14. doi: 10.1200/JCO.1999.17.6.1906. J Clin Oncol. 1999. PMID: 10561232 Clinical Trial.
Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography.
van Gijn R, van Tellingen O, de Clippeleir JJ, Hillebrand MJ, Boven E, Vermorken JB, ten Bokkel Huinink WW, Schwertz S, Graf P, Beijnen JH. van Gijn R, et al. Among authors: hillebrand mj. J Chromatogr B Biomed Appl. 1995 May 19;667(2):269-76. doi: 10.1016/0378-4347(95)00037-j. J Chromatogr B Biomed Appl. 1995. PMID: 7663699
Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction.
Rosing H, Hillebrand MJ, Jimeno JM, Gómez A, Floriano P, Faircloth G, Cameron L, Henrar RE, Vermorken JB, Bult A, Beijnen JH. Rosing H, et al. Among authors: hillebrand mj. J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):183-9. doi: 10.1016/s0378-4347(98)00143-1. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9686886
High-performance liquid chromatographic analysis of the investigational anticancer drug 9-aminocamptothecin, as the lactone form and as the total of the lactone and the hydroxycarboxylate forms, in micro-volumes of human plasma.
van Gijn R, Herben VM, Hillebrand MJ, ten Bokkel Huinink WW, Bult A, Beijnen JH. van Gijn R, et al. Among authors: hillebrand mj. J Pharm Biomed Anal. 1998 Sep;17(8):1257-65. doi: 10.1016/s0731-7085(97)00257-4. J Pharm Biomed Anal. 1998. PMID: 9800645
Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rosing H, Hillebrand MJ, Jimeno JM, Gómez A, Floriano P, Faircloth G, Henrar RE, Vermorken JB, Cvitkovic E, Bult A, Beijnen JH. Rosing H, et al. Among authors: hillebrand mj. J Mass Spectrom. 1998 Nov;33(11):1134-40. doi: 10.1002/(SICI)1096-9888(1998110)33:11<1134::AID-JMS730>3.0.CO;2-S. J Mass Spectrom. 1998. PMID: 9835068 Clinical Trial.
A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.
van Kesteren C, Mathĵt RA, López-Lázaro L, Cvitkovic E, Taamma A, Jimeno JM, Guzman C, Schellens JH, Misset JL, Brain E, Hillebrand MJ, Rosing H, Beijnen JH. van Kesteren C, et al. Among authors: hillebrand mj. Cancer Chemother Pharmacol. 2001 Dec;48(6):459-66. doi: 10.1007/s002800100368. Cancer Chemother Pharmacol. 2001. PMID: 11800026
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