Miller-Stein C - Search Results

1

Concurrent administration of the erythromycin breath test (EBT) and oral midazolam as in vivo probes for CYP3A activity.

McCrea J, Prueksaritanont T, Gertz BJ, Carides A, Gillen L, Antonello S, Brucker MJ, Miller-Stein C, Osborne B, Waldman S. McCrea J, et al. J Clin Pharmacol. 1999 Dec;39(12):1212-20. doi: 10.1177/00912709922012015. J Clin Pharmacol. 1999. PMID: 10586386 Clinical Trial.

2

Preclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences.

Roller S, Cui D, Laspina C, Miller-Stein C, Rowe J, Wong B, Prueksaritanont T. Roller S, et al. Among authors: miller stein c. Xenobiotica. 2009 Jan;39(1):33-45. doi: 10.1080/00498250802546861. Xenobiotica. 2009. PMID: 19219746

3

Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability.

Morrissette MM, Stauffer KJ, Williams PD, Lyle TA, Vacca JP, Krueger JA, Lewis SD, Lucas BJ, Wong BK, White RB, Miller-Stein C, Lyle EA, Wallace AA, Leonard YM, Welsh DC, Lynch JJ, McMasters DR. Morrissette MM, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4161-4. doi: 10.1016/j.bmcl.2004.06.030. Bioorg Med Chem Lett. 2004. PMID: 15261262

4

P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.

Isaacs RC, Newton CL, Cutrona KJ, Mercer SP, Dorsey BD, McDonough CM, Cook JJ, Krueger JA, Lewis SD, Lucas BJ, Lyle EA, Lynch JJ, Miller-Stein C, Michener MT, Wallace AA, White RB, Wong BK. Isaacs RC, et al. Among authors: miller stein c. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1532-5. doi: 10.1016/j.bmcl.2010.12.108. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21295466

5

Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel.

Bilodeau MT, Balitza AE, Koester TJ, Manley PJ, Rodman LD, Buser-Doepner C, Coll KE, Fernandes C, Gibbs JB, Heimbrook DC, Huckle WR, Kohl N, Lynch JJ, Mao X, McFall RC, McLoughlin D, Miller-Stein CM, Rickert KW, Sepp-Lorenzino L, Shipman JM, Subramanian R, Thomas KA, Wong BK, Yu S, Hartman GD. Bilodeau MT, et al. J Med Chem. 2004 Dec 2;47(25):6363-72. doi: 10.1021/jm049697f. J Med Chem. 2004. PMID: 15566305

6

Hydrophilic interaction chromatography/tandem mass spectrometry for the simultaneous determination of three polar non-structurally related compounds, imipenem, cilastatin and an investigational beta-lactamase inhibitor, MK-4698, in biological matrices.

Xu Y, Xie W, Miller-Stein CM, Woolf EJ. Xu Y, et al. Among authors: miller stein cm. Rapid Commun Mass Spectrom. 2009 Jul;23(14):2195-205. doi: 10.1002/rcm.4138. Rapid Commun Mass Spectrom. 2009. PMID: 19530150

7

Determination of chiral sulfoxides in plasma by normal-phase liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.

Miller-Stein C, Fernandez-Metzler C. Miller-Stein C, et al. J Chromatogr A. 2002 Jul 26;964(1-2):161-8. doi: 10.1016/s0021-9673(02)00667-2. J Chromatogr A. 2002. PMID: 12198844

8

Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.

Brady SF, Pawluczyk JM, Lumma PK, Feng DM, Wai JM, Jones R, DeFeo-Jones D, Wong BK, Miller-Stein C, Lin JH, Oliff A, Freidinger RM, Garsky VM. Brady SF, et al. J Med Chem. 2002 Oct 10;45(21):4706-15. doi: 10.1021/jm020139f. J Med Chem. 2002. PMID: 12361397

9

Automation of in-tip solid-phase microextraction in 96-well format for the determination of a model drug compound in human plasma by liquid chromatography with tandem mass spectrometric detection.

Xie W, Mullett WM, Miller-Stein CM, Pawliszyn J. Xie W, et al. Among authors: miller stein cm. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 1;877(4):415-20. doi: 10.1016/j.jchromb.2008.12.036. Epub 2008 Dec 25. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19144575

10

9-hydroxyazafluorenes and their use in thrombin inhibitors.

Stauffer KJ, Williams PD, Selnick HG, Nantermet PG, Newton CL, Homnick CF, Zrada MM, Lewis SD, Lucas BJ, Krueger JA, Pietrak BL, Lyle EA, Singh R, Miller-Stein C, White RB, Wong B, Wallace AA, Sitko GR, Cook JJ, Holahan MA, Stranieri-Michener M, Leonard YM, Lynch JJ Jr, McMasters DR, Yan Y. Stauffer KJ, et al. J Med Chem. 2005 Apr 7;48(7):2282-93. doi: 10.1021/jm049423s. J Med Chem. 2005. PMID: 15801822

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