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1-Methyl-4-phenylpyridinium ion (MPP+) selectively inhibits the replication of mitochondrial DNA.
Miyako K, Irie T, Muta T, Umeda S, Kai Y, Fujiwara T, Takeshige K, Kang D. Miyako K, et al. Eur J Biochem. 1999 Jan;259(1-2):412-8. doi: 10.1046/j.1432-1327.1999.00056.x. Eur J Biochem. 1999. PMID: 9914521 Free article.
We have previously reported that MPP+ decreases the content of mitochondrial DNA (mtDNA) independently of the inhibition of complex I in human cells [Miyako, K., Kai, Y., Irie, T., Takeshige, K., and Kang, D. (1997) J. Biol. Chem. 272, 9605-9608]. ...
We have previously reported that MPP+ decreases the content of mitochondrial DNA (mtDNA) independently of the inhibition of complex I in hum …
66 results