Nicolaou KC - Search Results

1

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.

Giannakakou P, Gussio R, Nogales E, Downing KH, Zaharevitz D, Bollbuck B, Poy G, Sackett D, Nicolaou KC, Fojo T. Giannakakou P, et al. Among authors: nicolaou kc. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2904-9. doi: 10.1073/pnas.040546297. Proc Natl Acad Sci U S A. 2000. PMID: 10688884 Free PMC article.

2

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.

Giannakakou P, Nakano M, Nicolaou KC, O'Brate A, Yu J, Blagosklonny MV, Greber UF, Fojo T. Giannakakou P, et al. Among authors: nicolaou kc. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10855-60. doi: 10.1073/pnas.132275599. Epub 2002 Jul 26. Proc Natl Acad Sci U S A. 2002. PMID: 12145320 Free PMC article.

3

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. Hamel E, et al. Among authors: nicolaou kc. Biochemistry. 1999 Apr 27;38(17):5490-8. doi: 10.1021/bi983023n. Biochemistry. 1999. PMID: 10220336

4

Chemical synthesis and biological properties of pyridine epothilones.

Nicolaou KC, Scarpelli R, Bollbuck B, Werschkun B, Pereira MM, Wartmann M, Altmann KH, Zaharevitz D, Gussio R, Giannakakou P. Nicolaou KC, et al. Chem Biol. 2000 Aug;7(8):593-9. doi: 10.1016/s1074-5521(00)00006-5. Chem Biol. 2000. PMID: 11048950

5

Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.

Nicolaou KC, Hepworth D, King NP, Finlay MR, Scarpelli R, Pereira MM, Bollbuck B, Bigot A, Werschkun B, Winssinger N. Nicolaou KC, et al. Chemistry. 2000 Aug 4;6(15):2783-800. doi: 10.1002/1521-3765(20000804)6:15<2783::aid-chem2783>3.0.co;2-b. Chemistry. 2000. PMID: 10985727

6

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones.

Nicolaou KC, Namoto K, Li J, Ritzén A, Ulven T, Shoji M, Zaharevitz D, Gussio R, Sackett DL, Ward RD, Hensler A, Fojo T, Giannakakou P. Nicolaou KC, et al. Chembiochem. 2001 Jan 8;2(1):69-75. doi: 10.1002/1439-7633(20010105)2:1<69::AID-CBIC69>3.0.CO;2-8. Chembiochem. 2001. PMID: 11828429 No abstract available.

7

Synthesis of epothilones A and B in solid and solution phase.

Nicolaou KC, Winssinger N, Pastor J, Ninkovic S, Sarabia F, He Y, Vourloumis D, Yang Z, Li T, Giannakakou P, Hamel E. Nicolaou KC, et al. Nature. 1997 May 15;387(6630):268-72. doi: 10.1038/387268a0. Nature. 1997. PMID: 9153390

8

Molecular design and chemical synthesis of a highly potent epothilone.

Nicolaou KC, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A, Giannakakou P. Nicolaou KC, et al. ChemMedChem. 2006 Jan;1(1):41-4. doi: 10.1002/cmdc.200500056. ChemMedChem. 2006. PMID: 16892332 No abstract available.

9

Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.

Buey RM, Díaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou KC, Sasmal PK, Ritzén A, Namoto K. Buey RM, et al. Among authors: nicolaou kc. Chem Biol. 2004 Feb;11(2):225-36. doi: 10.1016/j.chembiol.2004.01.014. Chem Biol. 2004. PMID: 15123284

10

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

Nicolaou KC, Namoto K, Ritzén A, Ulven T, Shoji M, Li J, D'Amico G, Liotta D, French CT, Wartmann M, Altmann KH, Giannakakou P. Nicolaou KC, et al. J Am Chem Soc. 2001 Sep 26;123(38):9313-23. doi: 10.1021/ja011338b. J Am Chem Soc. 2001. PMID: 11562214

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