Brown PJ - Search Results

1

The PPARs: from orphan receptors to drug discovery.

Willson TM, Brown PJ, Sternbach DD, Henke BR. Willson TM, et al. Among authors: brown pj. J Med Chem. 2000 Feb 24;43(4):527-50. doi: 10.1021/jm990554g. J Med Chem. 2000. PMID: 10691680 Review. No abstract available.

2

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.

Brown PJ, Smith-Oliver TA, Charifson PS, Tomkinson NC, Fivush AM, Sternbach DD, Wade LE, Orband-Miller L, Parks DJ, Blanchard SG, Kliewer SA, Lehmann JM, Willson TM. Brown PJ, et al. Chem Biol. 1997 Dec;4(12):909-18. doi: 10.1016/s1074-5521(97)90299-4. Chem Biol. 1997. PMID: 9427656

3

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

Brown PJ, Winegar DA, Plunket KD, Moore LB, Lewis MC, Wilson JG, Sundseth SS, Koble CS, Wu Z, Chapman JM, Lehmann JM, Kliewer SA, Willson TM. Brown PJ, et al. J Med Chem. 1999 Sep 23;42(19):3785-8. doi: 10.1021/jm9903601. J Med Chem. 1999. PMID: 10508427 No abstract available.

4

Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.

Liu KG, Lambert MH, Leesnitzer LM, Oliver W Jr, Ott RJ, Plunket KD, Stuart LW, Brown PJ, Willson TM, Sternbach DD. Liu KG, et al. Among authors: brown pj. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2959-62. doi: 10.1016/s0960-894x(01)00596-0. Bioorg Med Chem Lett. 2001. PMID: 11677135

5

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM. Kliewer SA, et al. Among authors: brown pj. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23. doi: 10.1073/pnas.94.9.4318. Proc Natl Acad Sci U S A. 1997. PMID: 9113987 Free PMC article.

6

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.

Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV. Xu HE, et al. Among authors: brown pj. Mol Cell. 1999 Mar;3(3):397-403. doi: 10.1016/s1097-2765(00)80467-0. Mol Cell. 1999. PMID: 10198642 Free article.

7

Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.

Brown PJ, Stuart LW, Hurley KP, Lewis MC, Winegar DA, Wilson JG, Wilkison WO, Ittoop OR, Willson TM. Brown PJ, et al. Bioorg Med Chem Lett. 2001 May 7;11(9):1225-7. doi: 10.1016/s0960-894x(01)00188-3. Bioorg Med Chem Lett. 2001. PMID: 11354382

8

Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: modification of the P1 and P2' residues.

Brown FK, Brown PJ, Bickett DM, Chambers CL, Davies HG, Deaton DN, Drewry D, Foley M, McElroy AB, Gregson M, et al. Brown FK, et al. Among authors: brown pj. J Med Chem. 1994 Mar 4;37(5):674-88. doi: 10.1021/jm00031a018. J Med Chem. 1994. PMID: 8126708

9

Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase.

Leeds JM, Brown PJ, McGeehan GM, Brown FK, Wiseman JS. Leeds JM, et al. Among authors: brown pj, brown fk. J Biol Chem. 1993 Aug 25;268(24):17781-6. J Biol Chem. 1993. PMID: 8349662 Free article.

10

Discovery of bioavailable inhibitors of secretory phospholipase A2.

Blanchard SG, Andrews RC, Brown PJ, Gan LS, Lee FW, Sinhababu AK, Wheeler TN. Blanchard SG, et al. Among authors: brown pj. Pharm Biotechnol. 1998;11:445-63. doi: 10.1007/0-306-47384-4_19. Pharm Biotechnol. 1998. PMID: 9760691 Review.

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