Henke BR - Search Results

1

The PPARs: from orphan receptors to drug discovery.

Willson TM, Brown PJ, Sternbach DD, Henke BR. Willson TM, et al. Among authors: henke br. J Med Chem. 2000 Feb 24;43(4):527-50. doi: 10.1021/jm990554g. J Med Chem. 2000. PMID: 10691680 Review. No abstract available.

2

Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.

Hirst GC, Aquino C, Birkemo L, Croom DK, Dezube M, Dougherty RW Jr, Ervin GN, Grizzle MK, Henke B, James MK, Johnson MF, Momtahen T, Queen KL, Sherrill RG, Szewczyk J, Willson TM, Sugg EE. Hirst GC, et al. J Med Chem. 1996 Dec 20;39(26):5236-45. doi: 10.1021/jm9601664. J Med Chem. 1996. PMID: 8978852

3

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.

Henke BR, Blanchard SG, Brackeen MF, Brown KK, Cobb JE, Collins JL, Harrington WW Jr, Hashim MA, Hull-Ryde EA, Kaldor I, Kliewer SA, Lake DH, Leesnitzer LM, Lehmann JM, Lenhard JM, Orband-Miller LA, Miller JF, Mook RA Jr, Noble SA, Oliver W Jr, Parks DJ, Plunket KD, Szewczyk JR, Willson TM. Henke BR, et al. J Med Chem. 1998 Dec 3;41(25):5020-36. doi: 10.1021/jm9804127. J Med Chem. 1998. PMID: 9836620

4

Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.

Henke BR, Adkison KK, Blanchard SG, Leesnitzer LM, Mook RA Jr, Plunket KD, Ray JA, Roberson C, Unwalla R, Willson TM. Henke BR, et al. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3329-34. doi: 10.1016/s0960-894x(99)00603-4. Bioorg Med Chem Lett. 1999. PMID: 10612594

5

Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta.

Liu KG, Smith JS, Ayscue AH, Henke BR, Lambert MH, Leesnitzer LM, Plunket KD, Willson TM, Sternbach DD. Liu KG, et al. Among authors: henke br. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2385-8. doi: 10.1016/s0960-894x(01)00458-9. Bioorg Med Chem Lett. 2001. PMID: 11527737

6

Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.

Liu KG, Lambert MH, Ayscue AH, Henke BR, Leesnitzer LM, Oliver WR Jr, Plunket KD, Xu HE, Sternbach DD, Willson TM. Liu KG, et al. Among authors: henke br. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3111-3. doi: 10.1016/s0960-894x(01)00649-7. Bioorg Med Chem Lett. 2001. PMID: 11720854

7

3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats.

Willson TM, Henke BR, Momtahen TM, Charifson PS, Batchelor KW, Lubahn DB, Moore LB, Oliver BB, Sauls HR, Triantafillou JA, et al. Willson TM, et al. Among authors: henke br. J Med Chem. 1994 May 27;37(11):1550-2. doi: 10.1021/jm00037a002. J Med Chem. 1994. PMID: 8201587 No abstract available.

8

3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents.

Henke BR, Willson TM, Sugg EE, Croom DK, Dougherty RW Jr, Queen KL, Birkemo LS, Ervin GN, Grizzle MK, Johnson MF, James MK. Henke BR, et al. J Med Chem. 1996 Jul 5;39(14):2655-8. doi: 10.1021/jm960249k. J Med Chem. 1996. PMID: 8709093 No abstract available.

9

3-[2-(N-phenylacetamide)]-1,5-benzodiazepines: orally active, binding selective CCK-A agonists.

Willson TM, Henke BR, Momtahen TM, Myers PL, Sugg EE, Unwalla RJ, Croom DK, Dougherty RW, Grizzle MK, Johnson MF, Queen KL, Rimele TJ, Yingling JD, James MK. Willson TM, et al. Among authors: henke br. J Med Chem. 1996 Jul 19;39(15):3030-4. doi: 10.1021/jm960205b. J Med Chem. 1996. PMID: 8709137

10

Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.

Henke BR, Aquino CJ, Birkemo LS, Croom DK, Dougherty RW Jr, Ervin GN, Grizzle MK, Hirst GC, James MK, Johnson MF, Queen KL, Sherrill RG, Sugg EE, Suh EM, Szewczyk JW, Unwalla RJ, Yingling J, Willson TM. Henke BR, et al. J Med Chem. 1997 Aug 15;40(17):2706-25. doi: 10.1021/jm970265x. J Med Chem. 1997. PMID: 9276016

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