Hersperger R - Search Results

1

Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.

Hersperger R, Bray-French K, Mazzoni L, Müller T. Hersperger R, et al. J Med Chem. 2000 Feb 24;43(4):675-82. doi: 10.1021/jm991094u. J Med Chem. 2000. PMID: 10691693

2

A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.

Hersperger R, Buchheit KH, Cammisuli S, Enz A, Lohse O, Ponelle M, Schuler W, Schweitzer A, Walker C, Zehender H, Zenke G, Zimmerlin AG, Zollinger M, Mazzoni L, Fozard JR. Hersperger R, et al. J Med Chem. 2004 Sep 23;47(20):4950-7. doi: 10.1021/jm031101l. J Med Chem. 2004. PMID: 15369399

3

Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities.

Trifilieff A, Wyss D, Walker C, Mazzoni L, Hersperger R. Trifilieff A, et al. Among authors: hersperger r. J Pharmacol Exp Ther. 2002 Apr;301(1):241-8. doi: 10.1124/jpet.301.1.241. J Pharmacol Exp Ther. 2002. PMID: 11907180

4

Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor.

Hersperger R, Dawson J, Mueller T. Hersperger R, et al. Bioorg Med Chem Lett. 2002 Jan 21;12(2):233-5. doi: 10.1016/s0960-894x(01)00720-x. Bioorg Med Chem Lett. 2002. PMID: 11755362

5

Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK.

Waelchli R, Bollbuck B, Bruns C, Buhl T, Eder J, Feifel R, Hersperger R, Janser P, Revesz L, Zerwes HG, Schlapbach A. Waelchli R, et al. Among authors: hersperger r. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12. doi: 10.1016/j.bmcl.2005.09.035. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236504

6

An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.

Angst D, Janser P, Quancard J, Buehlmayer P, Berst F, Oberer L, Beerli C, Streiff M, Pally C, Hersperger R, Bruns C, Bassilana F, Bollbuck B. Angst D, et al. Among authors: hersperger r. J Med Chem. 2012 Nov 26;55(22):9722-34. doi: 10.1021/jm3009508. Epub 2012 Oct 26. J Med Chem. 2012. PMID: 23067318

7

Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin.

Hersperger R, Schuler W, Zenke G. Hersperger R, et al. Bioorg Med Chem Lett. 1999 Jan 18;9(2):227-32. doi: 10.1016/s0960-894x(98)00702-1. Bioorg Med Chem Lett. 1999. PMID: 10021934

8

Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.

Pulz R, Angst D, Dawson J, Gessier F, Gutmann S, Hersperger R, Hinniger A, Janser P, Koch G, Revesz L, Vulpetti A, Waelchli R, Zimmerlin A, Cenni B. Pulz R, et al. Among authors: hersperger r. ACS Med Chem Lett. 2019 Sep 6;10(10):1467-1472. doi: 10.1021/acsmedchemlett.9b00317. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620235 Free PMC article.

9

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.

Quancard J, Bollbuck B, Janser P, Angst D, Berst F, Buehlmayer P, Streiff M, Beerli C, Brinkmann V, Guerini D, Smith PA, Seabrook TJ, Traebert M, Seuwen K, Hersperger R, Bruns C, Bassilana F, Bigaud M. Quancard J, et al. Among authors: hersperger r. Chem Biol. 2012 Sep 21;19(9):1142-51. doi: 10.1016/j.chembiol.2012.07.016. Chem Biol. 2012. PMID: 22999882

10

Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure.

Velcicky J, Schlapbach A, Heng R, Revesz L, Pflieger D, Blum E, Hawtin S, Huppertz C, Feifel R, Hersperger R. Velcicky J, et al. Among authors: hersperger r. ACS Med Chem Lett. 2018 Mar 20;9(4):392-396. doi: 10.1021/acsmedchemlett.8b00098. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29670707 Free PMC article.

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