Thomas AP - Search Results

1

ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy.

Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Curwen JO, Hennequin LF, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF. Wedge SR, et al. Among authors: thomas ap. Cancer Res. 2000 Feb 15;60(4):970-5. Cancer Res. 2000. PMID: 10706112

2

ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, Boffey SJ, Valentine PJ, Curwen JO, Musgrove HL, Graham GA, Hughes GD, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF, Bigley AL, Hennequin LF. Wedge SR, et al. Among authors: thomas ap. Cancer Res. 2002 Aug 15;62(16):4645-55. Cancer Res. 2002. PMID: 12183421

3

Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors.

Hennequin LF, Stokes ES, Thomas AP, Johnstone C, Plé PA, Ogilvie DJ, Dukes M, Wedge SR, Kendrew J, Curwen JO. Hennequin LF, et al. Among authors: thomas ap. J Med Chem. 2002 Mar 14;45(6):1300-12. doi: 10.1021/jm011022e. J Med Chem. 2002. PMID: 11881999

4

Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.

Hennequin LF, Thomas AP, Johnstone C, Stokes ES, Plé PA, Lohmann JJ, Ogilvie DJ, Dukes M, Wedge SR, Curwen JO, Kendrew J, Lambert-van der Brempt C. Hennequin LF, et al. Among authors: thomas ap. J Med Chem. 1999 Dec 30;42(26):5369-89. doi: 10.1021/jm990345w. J Med Chem. 1999. PMID: 10639280

5

AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family.

Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S, Rooney C, Coleman T, Baker D, Mellor MJ, Brooks AN, Klinowska T. Gavine PR, et al. Among authors: thomas ap. Cancer Res. 2012 Apr 15;72(8):2045-56. doi: 10.1158/0008-5472.CAN-11-3034. Epub 2012 Feb 27. Cancer Res. 2012. PMID: 22369928

6

AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.

Byth KF, Thomas A, Hughes G, Forder C, McGregor A, Geh C, Oakes S, Green C, Walker M, Newcombe N, Green S, Growcott J, Barker A, Wilkinson RW. Byth KF, et al. Mol Cancer Ther. 2009 Jul;8(7):1856-66. doi: 10.1158/1535-7163.MCT-08-0836. Epub 2009 Jun 9. Mol Cancer Ther. 2009. PMID: 19509270

7

Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors.

Byth KF, Cooper N, Culshaw JD, Heaton DW, Oakes SE, Minshull CA, Norman RA, Pauptit RA, Tucker JA, Breed J, Pannifer A, Rowsell S, Stanway JJ, Valentine AL, Thomas AP. Byth KF, et al. Among authors: thomas ap. Bioorg Med Chem Lett. 2004 May 3;14(9):2249-52. doi: 10.1016/j.bmcl.2004.02.008. Bioorg Med Chem Lett. 2004. PMID: 15081018

8

The cellular phenotype of AZ703, a novel selective imidazo[1,2-a]pyridine cyclin-dependent kinase inhibitor.

Byth KF, Geh C, Forder CL, Oakes SE, Thomas AP. Byth KF, et al. Among authors: thomas ap. Mol Cancer Ther. 2006 Mar;5(3):655-64. doi: 10.1158/1535-7163.MCT-05-0205. Mol Cancer Ther. 2006. PMID: 16546980

9

Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors.

Byth KF, Culshaw JD, Green S, Oakes SE, Thomas AP. Byth KF, et al. Among authors: thomas ap. Bioorg Med Chem Lett. 2004 May 3;14(9):2245-8. doi: 10.1016/j.bmcl.2004.02.015. Bioorg Med Chem Lett. 2004. PMID: 15081017

10

Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation.

Anderson M, Beattie JF, Breault GA, Breed J, Byth KF, Culshaw JD, Ellston RP, Green S, Minshull CA, Norman RA, Pauptit RA, Stanway J, Thomas AP, Jewsbury PJ. Anderson M, et al. Among authors: thomas ap. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3021-6. doi: 10.1016/s0960-894x(03)00638-3. Bioorg Med Chem Lett. 2003. PMID: 12941325

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