Leach CA - Search Results

1

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Flynn ST, Hickey DM, Ife RJ, Jones M, Leach CA, Macphee CH, Milliner KJ, Rawlings DA, Slingsby BP, Smith SA, Stansfield IG, Tew DG, Theobald CJ. Boyd HF, et al. Among authors: leach ca. Bioorg Med Chem Lett. 2000 Feb 21;10(4):395-8. doi: 10.1016/s0960-894x(00)00002-0. Bioorg Med Chem Lett. 2000. PMID: 10714508

2

Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.

Boyd HF, Fell SC, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Pinto IL, Rawlings DA, Smith SA, Stansfield IG, Stanway SJ, Theobald CJ, Whittaker CM. Boyd HF, et al. Among authors: leach ca. Bioorg Med Chem Lett. 2002 Jan 7;12(1):51-5. doi: 10.1016/s0960-894x(01)00678-3. Bioorg Med Chem Lett. 2002. PMID: 11738571

3

The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.

Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Elliott RL, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ, Whittaker CM. Blackie JA, et al. Among authors: leach ca. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2603-6. doi: 10.1016/s0960-894x(02)00473-0. Bioorg Med Chem Lett. 2002. PMID: 12182870

4

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ. Blackie JA, et al. Among authors: leach ca. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70. doi: 10.1016/s0960-894x(03)00058-1. Bioorg Med Chem Lett. 2003. PMID: 12643913

5

Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-substituted-4-(phenylamino)quinolines.

Ife RJ, Brown TH, Keeling DJ, Leach CA, Meeson ML, Parsons ME, Reavill DR, Theobald CJ, Wiggall KJ. Ife RJ, et al. Among authors: leach ca. J Med Chem. 1992 Sep 4;35(18):3413-22. doi: 10.1021/jm00096a018. J Med Chem. 1992. PMID: 1326634

6

Reversible inhibitors of the gastric (H+/K+)-ATPase. 4. Identification of an inhibitor with an intermediate duration of action.

Leach CA, Brown TH, Ife RJ, Keeling DJ, Parsons ME, Theobald CJ, Wiggall KJ. Leach CA, et al. J Med Chem. 1995 Jul 7;38(14):2748-62. doi: 10.1021/jm00014a026. J Med Chem. 1995. PMID: 7629813

7

Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2,4-diaminoquinazolines and thienopyrimidines.

Ife RJ, Brown TH, Blurton P, Keeling DJ, Leach CA, Meeson ML, Parsons ME, Theobald CJ. Ife RJ, et al. Among authors: leach ca. J Med Chem. 1995 Jul 7;38(14):2763-73. doi: 10.1021/jm00014a027. J Med Chem. 1995. PMID: 7629814

8

Mechanism of inhibition of LDL phospholipase A2 by monocyclic-beta-lactams. Burst kinetics and the effect of stereochemistry.

Tew DG, Boyd HF, Ashman S, Theobald C, Leach CA. Tew DG, et al. Among authors: leach ca. Biochemistry. 1998 Jul 14;37(28):10087-93. doi: 10.1021/bi9801412. Biochemistry. 1998. PMID: 9665713

9

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor.

MacPhee CH, Moores KE, Boyd HF, Dhanak D, Ife RJ, Leach CA, Leake DS, Milliner KJ, Patterson RA, Suckling KE, Tew DG, Hickey DM. MacPhee CH, et al. Among authors: leach ca. Biochem J. 1999 Mar 1;338 ( Pt 2)(Pt 2):479-87. Biochem J. 1999. PMID: 10024526 Free PMC article.

10

N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Fell SC, Flynn ST, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Porter RA, Rawlings DA, Smith SA, Stansfield IG, Tew DG, Theobald CJ, Whittaker CM. Boyd HF, et al. Among authors: leach ca. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2557-61. doi: 10.1016/s0960-894x(00)00510-2. Bioorg Med Chem Lett. 2000. PMID: 11086729

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