Smith SA - Search Results

1

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Flynn ST, Hickey DM, Ife RJ, Jones M, Leach CA, Macphee CH, Milliner KJ, Rawlings DA, Slingsby BP, Smith SA, Stansfield IG, Tew DG, Theobald CJ. Boyd HF, et al. Among authors: smith sa. Bioorg Med Chem Lett. 2000 Feb 21;10(4):395-8. doi: 10.1016/s0960-894x(00)00002-0. Bioorg Med Chem Lett. 2000. PMID: 10714508

2

Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.

Boyd HF, Fell SC, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Pinto IL, Rawlings DA, Smith SA, Stansfield IG, Stanway SJ, Theobald CJ, Whittaker CM. Boyd HF, et al. Among authors: smith sa. Bioorg Med Chem Lett. 2002 Jan 7;12(1):51-5. doi: 10.1016/s0960-894x(01)00678-3. Bioorg Med Chem Lett. 2002. PMID: 11738571

3

The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.

Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Elliott RL, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ, Whittaker CM. Blackie JA, et al. Among authors: smith sa. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2603-6. doi: 10.1016/s0960-894x(02)00473-0. Bioorg Med Chem Lett. 2002. PMID: 12182870

4

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ. Blackie JA, et al. Among authors: smith sa. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70. doi: 10.1016/s0960-894x(03)00058-1. Bioorg Med Chem Lett. 2003. PMID: 12643913

5

N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Fell SC, Flynn ST, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Porter RA, Rawlings DA, Smith SA, Stansfield IG, Tew DG, Theobald CJ, Whittaker CM. Boyd HF, et al. Among authors: smith sa. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2557-61. doi: 10.1016/s0960-894x(00)00510-2. Bioorg Med Chem Lett. 2000. PMID: 11086729

6

The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2.

Boyd HF, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Pinto IL, Smith SA, Stansfield IG, Theobald CJ, Whittaker CM. Boyd HF, et al. Among authors: smith sa. Bioorg Med Chem Lett. 2001 Mar 12;11(5):701-4. doi: 10.1016/s0960-894x(01)00038-5. Bioorg Med Chem Lett. 2001. PMID: 11266173

7

Lipoprotein-associated PLA2 inhibition--a novel, non-lipid lowering strategy for atherosclerosis therapy.

Leach CA, Hickey DM, Ife RJ, Macphee CH, Smith SA, Tew DG. Leach CA, et al. Among authors: smith sa. Farmaco. 2001 Jan-Feb;56(1-2):45-50. doi: 10.1016/s0014-827x(01)01011-4. Farmaco. 2001. PMID: 11347966

8

1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2).

Bloomer JC, Boyd HF, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Pinto IL, Rawlings DA, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ, Whittaker CM. Bloomer JC, et al. Among authors: smith sa. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1925-9. doi: 10.1016/s0960-894x(01)00346-8. Bioorg Med Chem Lett. 2001. PMID: 11459662

9

Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

Patel L, Pass I, Coxon P, Downes CP, Smith SA, Macphee CH. Patel L, et al. Among authors: smith sa. Curr Biol. 2001 May 15;11(10):764-8. doi: 10.1016/s0960-9822(01)00225-1. Curr Biol. 2001. PMID: 11378386 Free article.

10

Synthesis of novel modified dipeptide inhibitors of human collagenase: beta-mercapto carboxylic acid derivatives.

Beszant B, Bird J, Gaster LM, Harper GP, Hughes I, Karran EH, Markwell RE, Miles-Williams AJ, Smith SA. Beszant B, et al. Among authors: smith sa. J Med Chem. 1993 Dec 10;36(25):4030-9. doi: 10.1021/jm00077a006. J Med Chem. 1993. PMID: 8258825

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

1,641 results

Search Page

Filters