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Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).
Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR. Dahlberg L, et al. Among authors: zukor d. Arthritis Rheum. 2000 Mar;43(3):673-82. doi: 10.1002/1529-0131(200003)43:3<673::AID-ANR25>3.0.CO;2-8. Arthritis Rheum. 2000. PMID: 10728762 Free article.
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.
Tchetina EV, Di Battista JA, Zukor DJ, Antoniou J, Poole AR. Tchetina EV, et al. Arthritis Res Ther. 2007;9(4):R75. doi: 10.1186/ar2273. Arthritis Res Ther. 2007. PMID: 17683641 Free PMC article.
101 results