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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C. Steiner H, et al. Among authors: keck s. J Biol Chem. 1999 Oct 1;274(40):28669-73. doi: 10.1074/jbc.274.40.28669. J Biol Chem. 1999. PMID: 10497236 Free article.
CD14 is required for MyD88-independent LPS signaling.
Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B. Jiang Z, et al. Among authors: keck s. Nat Immunol. 2005 Jun;6(6):565-70. doi: 10.1038/ni1207. Epub 2005 May 15. Nat Immunol. 2005. PMID: 15895089
R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells.
Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Beutler B, Galanos C, Freudenberg MA. Huber M, et al. Among authors: keck s. Eur J Immunol. 2006 Mar;36(3):701-11. doi: 10.1002/eji.200535593. Eur J Immunol. 2006. PMID: 16506285 Free article.
Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.
Fejer G, Drechsel L, Liese J, Schleicher U, Ruzsics Z, Imelli N, Greber UF, Keck S, Hildenbrand B, Krug A, Bogdan C, Freudenberg MA. Fejer G, et al. Among authors: keck s. PLoS Pathog. 2008 Nov;4(11):e1000208. doi: 10.1371/journal.ppat.1000208. Epub 2008 Nov 14. PLoS Pathog. 2008. PMID: 19008951 Free PMC article.
61 results