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Page 1
An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists.
Lewis RT, Ladduwahetty T, Merchant KJ, Keown LE, Hitzel L, Verrier H, Stevenson GI, MacLeod AM. Lewis RT, et al. Among authors: ladduwahetty t. J Org Chem. 2000 Apr 21;65(8):2615-8. doi: 10.1021/jo9918246. J Org Chem. 2000. PMID: 10789488 No abstract available.
4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.
Stevenson GI, Huscroft I, MacLeod AM, Swain CJ, Cascieri MA, Chicchi GG, Graham MI, Harrison T, Kelleher FJ, Kurtz M, Ladduwahetty T, Merchant KJ, Metzger JM, MacIntyre DE, Sadowski S, Sohal B, Owens AP. Stevenson GI, et al. Among authors: ladduwahetty t. J Med Chem. 1998 Nov 5;41(23):4623-35. doi: 10.1021/jm980376b. J Med Chem. 1998. PMID: 9804702
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.
Fish LR, Gilligan MT, Humphries AC, Ivarsson M, Ladduwahetty T, Merchant KJ, O'Connor D, Patel S, Philipps E, Vargas HM, Hutson PH, MacLeod AM. Fish LR, et al. Among authors: ladduwahetty t. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3665-9. doi: 10.1016/j.bmcl.2005.05.104. Bioorg Med Chem Lett. 2005. PMID: 15993598
Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.
Ladduwahetty T, Gilligan M, Humphries A, Merchant KJ, Fish R, McAlister G, Ivarsson M, Dominguez M, O'Connor D, MacLeod AM. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12. doi: 10.1016/j.bmcl.2010.04.090. Epub 2010 Apr 24. Bioorg Med Chem Lett. 2010. PMID: 20493697
Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.
Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, Ladduwahetty T, Keown L, Swain C, Baker R, Cascieri M, Ber E, Metzger J, MacIntyre DE, Hill RG, Hargreaves RJ. Tattersall FD, et al. Among authors: ladduwahetty t. Neuropharmacology. 1996;35(8):1121-9. doi: 10.1016/s0028-3908(96)00020-2. Neuropharmacology. 1996. PMID: 9121615
A new class of selective, non-basic 5-HT2A receptor antagonists.
Ladduwahetty T, Boase AL, Mitchinson A, Quin C, Patel S, Chapman K, MacLeod AM. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3201-4. doi: 10.1016/j.bmcl.2006.03.050. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16632354
CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.
Cansfield AD, Ladduwahetty T, Sunose M, Ellard K, Lynch R, Newton AL, Lewis A, Bennett G, Zinn N, Thomson DW, Rüger AJ, Feutrill JT, Rausch O, Watt AP, Bergamini G. Cansfield AD, et al. Among authors: ladduwahetty t. ACS Med Chem Lett. 2016 Jun 10;7(8):768-73. doi: 10.1021/acsmedchemlett.6b00149. eCollection 2016 Aug 11. ACS Med Chem Lett. 2016. PMID: 27563401 Free PMC article.
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
Ladduwahetty T, Lee MR, Maillard MC, Cachope R, Todd D, Barnes M, Beaumont V, Chauhan A, Gallati C, Haughan AF, Kempf G, Luckhurst CA, Matthews K, McAllister G, Mitchell P, Patel H, Rose M, Saville-Stones E, Steinbacher S, Stott AJ, Thatcher E, Tierney J, Urbonas L, Munoz-Sanjuan I, Dominguez C. Ladduwahetty T, et al. J Med Chem. 2022 Jul 28;65(14):9819-9845. doi: 10.1021/acs.jmedchem.2c00474. Epub 2022 Jul 11. J Med Chem. 2022. PMID: 35816678
15 results