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Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans.
Schwartz JI, Chan CC, Mukhopadhyay S, McBride KJ, Jones TM, Adcock S, Moritz C, Hedges J, Grasing K, Dobratz D, Cohen RA, Davidson MH, Bachmann KA, Gertz BJ. Schwartz JI, et al. Clin Pharmacol Ther. 1999 Jun;65(6):653-60. doi: 10.1016/S0009-9236(99)90087-5. Clin Pharmacol Ther. 1999. PMID: 10391671 Clinical Trial.
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