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CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology.
Tecle H, Schwarz RD, Barrett SD, Callahan MJ, Caprathe BW, Davis RE, Doyle P, Emmerling M, Lauffer DJ, Mirzadegan T, Moreland DW, Lipiniski W, Nelson C, Raby C, Spencer C, Spiegel K, Thomas AJ, Jaen JC. Tecle H, et al. Among authors: callahan mj. Pharm Acta Helv. 2000 Mar;74(2-3):141-8. doi: 10.1016/s0031-6865(99)00027-8. Pharm Acta Helv. 2000. PMID: 10812951
PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist.
Emmerling MR, Gregor VE, Schwarz RD, Scholten JD, Callahan MJ, Lee C, Moore CJ, Raby C, Lipinski WJ, Davis RE. Emmerling MR, et al. Among authors: callahan mj. Mol Neurobiol. 1994 Aug-Dec;9(1-3):93-106. doi: 10.1007/BF02816108. Mol Neurobiol. 1994. PMID: 7888109
Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.
Tecle H, Barrett SD, Lauffer DJ, Augelli-Szafran C, Brann MR, Callahan MJ, Caprathe BW, Davis RE, Doyle PD, Eubanks D, Lipiniski W, Mirzadegan T, Moos WH, Moreland DW, Nelson CB, Pavia MR, Raby C, Schwarz RD, Spencer CJ, Thomas AJ, Jaen JC. Tecle H, et al. Among authors: callahan mj. J Med Chem. 1998 Jul 2;41(14):2524-36. doi: 10.1021/jm960683m. J Med Chem. 1998. PMID: 9651157
The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors.
Simons LJ, Caprathe BW, Callahan M, Graham JM, Kimura T, Lai Y, LeVine H 3rd, Lipinski W, Sakkab AT, Tasaki Y, Walker LC, Yasunaga T, Ye Y, Zhuang N, Augelli-Szafran CE. Simons LJ, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):654-7. doi: 10.1016/j.bmcl.2008.12.049. Epub 2008 Dec 24. Bioorg Med Chem Lett. 2009. PMID: 19121939
175 results