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Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.
Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR. Jarvest RL, et al. Among authors: forrest ak. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41. doi: 10.1016/j.bmcl.2004.05.070. Bioorg Med Chem Lett. 2004. PMID: 15225702
Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.
Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A. Jarvest RL, et al. Among authors: forrest ak. J Med Chem. 2002 May 9;45(10):1959-62. doi: 10.1021/jm025502x. J Med Chem. 2002. PMID: 11985462
Analogues of SB-203207 as inhibitors of tRNA synthetases.
Banwell MG, Crasto CF, Easton CJ, Forrest AK, Karoli T, March DR, Mensah L, Nairn MR, O'Hanlon PJ, Oldham MD, Yue W. Banwell MG, et al. Among authors: forrest ak. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2263-6. doi: 10.1016/s0960-894x(00)00456-x. Bioorg Med Chem Lett. 2000. PMID: 11055334
Erythromycin A oxime 11,12-carbonate and its oxime ethers.
Brain EG, Forrest AK, Hunt E, Shillingford C, Wilson JM. Brain EG, et al. Among authors: forrest ak. J Antibiot (Tokyo). 1989 Dec;42(12):1817-22. doi: 10.7164/antibiotics.42.1817. J Antibiot (Tokyo). 1989. PMID: 2621163 Free article.
22 results