Higuchi S - Search Results

1

Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele.

Shimamoto J, Ieiri I, Urae A, Kimura M, Irie S, Kubota T, Chiba K, Ishizaki T, Otsubo K, Higuchi S. Shimamoto J, et al. Among authors: higuchi s. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. doi: 10.1007/s002280050722. Eur J Clin Pharmacol. 2000. PMID: 10853880

2

The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.

Mamiya K, Ieiri I, Shimamoto J, Yukawa E, Imai J, Ninomiya H, Yamada H, Otsubo K, Higuchi S, Tashiro N. Mamiya K, et al. Among authors: higuchi s. Epilepsia. 1998 Dec;39(12):1317-23. doi: 10.1111/j.1528-1157.1998.tb01330.x. Epilepsia. 1998. PMID: 9860067 Free article.

3

Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy.

Kimura M, Ieiri I, Wada Y, Mamiya K, Urae A, Iimori E, Sakai T, Otsubo K, Higuchi S. Kimura M, et al. Among authors: higuchi s. Br J Clin Pharmacol. 1999 Jan;47(1):115-9. doi: 10.1046/j.1365-2125.1999.00858.x. Br J Clin Pharmacol. 1999. PMID: 10073749 Free PMC article. Clinical Trial.

4

Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects.

Takanaga H, Ohnishi A, Murakami H, Matsuo H, Higuchi S, Urae A, Irie S, Furuie H, Matsukuma K, Kimura M, Kawano K, Orii Y, Tanaka T, Sawada Y. Takanaga H, et al. Among authors: higuchi s. Clin Pharmacol Ther. 2000 Mar;67(3):201-14. doi: 10.1067/mcp.2000.104215. Clin Pharmacol Ther. 2000. PMID: 10741622 Clinical Trial.

5

CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics.

Mamiya K, Hadama A, Yukawa E, Ieiri I, Otsubo K, Ninomiya H, Tashiro N, Higuchi S. Mamiya K, et al. Among authors: higuchi s. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):821-5. doi: 10.1007/s002280050703. Eur J Clin Pharmacol. 2000. PMID: 10805060 Clinical Trial.

6

Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies.

Shintani M, Ieiri I, Inoue K, Mamiya K, Ninomiya H, Tashiro N, Higuchi S, Otsubo K. Shintani M, et al. Among authors: higuchi s. Clin Pharmacol Ther. 2001 Aug;70(2):175-82. doi: 10.1067/mcp.2001.117367. Clin Pharmacol Ther. 2001. PMID: 11503012

7

SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers.

Ieiri I, Suwannakul S, Maeda K, Uchimaru H, Hashimoto K, Kimura M, Fujino H, Hirano M, Kusuhara H, Irie S, Higuchi S, Sugiyama Y. Ieiri I, et al. Among authors: higuchi s. Clin Pharmacol Ther. 2007 Nov;82(5):541-7. doi: 10.1038/sj.clpt.6100190. Epub 2007 Apr 25. Clin Pharmacol Ther. 2007. PMID: 17460607 Clinical Trial.

8

Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, C gamma P2C19m1 in exon 5 and C gamma P2C19m2 in exon 4, in Japanese subjects.

Ieiri I, Kubota T, Urae A, Kimura M, Wada Y, Mamiya K, Yoshioka S, Irie S, Amamoto T, Nakamura K, Nakano S, Higuchi S. Ieiri I, et al. Among authors: higuchi s. Clin Pharmacol Ther. 1996 Jun;59(6):647-53. doi: 10.1016/S0009-9236(96)90004-1. Clin Pharmacol Ther. 1996. PMID: 8681489

9

Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.

Ieiri I, Mamiya K, Urae A, Wada Y, Kimura M, Irie S, Amamoto T, Kubota T, Yoshioka S, Nakamura K, Nakano S, Tashiro N, Higuchi S. Ieiri I, et al. Among authors: higuchi s. Br J Clin Pharmacol. 1997 Apr;43(4):441-5. doi: 10.1046/j.1365-2125.1997.00572.x. Br J Clin Pharmacol. 1997. PMID: 9146858 Free PMC article. Clinical Trial.

10

Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population.

Kimura M, Ieiri I, Mamiya K, Urae A, Higuchi S. Kimura M, et al. Among authors: higuchi s. Ther Drug Monit. 1998 Jun;20(3):243-7. doi: 10.1097/00007691-199806000-00001. Ther Drug Monit. 1998. PMID: 9631918

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