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Page 1
Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
Nomeir AA, Pramanik BN, Heimark L, Bennett F, Veals J, Bartner P, Hilbert M, Saksena A, McNamara P, Girijavallabhan V, Ganguly AK, Lovey R, Pike R, Wang H, Liu YT, Kumari P, Korfmacher W, Lin CC, Cacciapuoti A, Loebenberg D, Hare R, Miller G, Pickett C. Nomeir AA, et al. Among authors: heimark l. J Mass Spectrom. 2008 Apr;43(4):509-17. doi: 10.1002/jms.1341. J Mass Spectrom. 2008. PMID: 18059003
Analogues of 1-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo-[5,6]-cyclohepta [1,2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase.
Afonso A, Weinstein J, Kelly J, Wolin R, Rosenblum SB, Connolly M, Guzi T, James L, Carr D, Patton R, Bishop WR, Kirshmeier P, Liu M, Heimark L, Chen KJ, Nomeir AA. Afonso A, et al. Among authors: heimark l. Bioorg Med Chem. 1999 Sep;7(9):1845-55. doi: 10.1016/s0968-0896(99)00103-0. Bioorg Med Chem. 1999. PMID: 10530932
Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma.
Wang G, Hsieh Y, Cheng KC, Morrison RA, Venkatraman S, Njoroge FG, Heimark L, Korfmacher WA. Wang G, et al. Among authors: heimark l. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):92-100. doi: 10.1016/j.jchromb.2006.12.038. Epub 2007 Jan 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17240204
Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
Munayyer HK, Mann PA, Chau AS, Yarosh-Tomaine T, Greene JR, Hare RS, Heimark L, Palermo RE, Loebenberg D, McNicholas PM. Munayyer HK, et al. Among authors: heimark l. Antimicrob Agents Chemother. 2004 Oct;48(10):3690-6. doi: 10.1128/AAC.48.10.3690-3696.2004. Antimicrob Agents Chemother. 2004. PMID: 15388421 Free PMC article.
High-resolution LC/MS for analysis of minor components in complex mixtures: negative ion ESI for identification of impurities and degradation products of a novel oligosaccharide antibiotic.
Shipkova PA, Heimark L, Bartner PL, Chen G, Pramanik BN, Ganguly AK, Cody RB, Kusai A. Shipkova PA, et al. Among authors: heimark l. J Mass Spectrom. 2000 Nov;35(11):1252-8. doi: 10.1002/1096-9888(200011)35:11<1252::AID-JMS56>3.0.CO;2-J. J Mass Spectrom. 2000. PMID: 11114082
Isolation, structural determination, synthesis and quantitative determination of impurities in Intron-A, leached from a silicone tubing.
Chan TM, Pramanik B, Aslanian R, Gullo V, Patel M, Cronin B, Boyce C, McCormick K, Berlin M, Zhu X, Buevich A, Heimark L, Bartner P, Chen G, Pu H, Hegde V. Chan TM, et al. Among authors: heimark l. J Pharm Biomed Anal. 2009 Feb 20;49(2):327-32. doi: 10.1016/j.jpba.2008.11.038. Epub 2008 Dec 6. J Pharm Biomed Anal. 2009. PMID: 19150187
Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.
Taveras AG, Deskus J, Chao J, Vaccaro CJ, Njoroge FG, Vibulbhan B, Pinto P, Remiszewski S, del Rosario J, Doll RJ, Alvarez C, Lalwani T, Mallams AK, Rossman RR, Afonso A, Girijavallabhan VM, Ganguly AK, Pramanik B, Heimark L, Bishop WR, Wang L, Kirschmeier P, James L, Carr D, Liu M, et al. Taveras AG, et al. Among authors: heimark l. J Med Chem. 1999 Jul 15;42(14):2651-61. doi: 10.1021/jm990059k. J Med Chem. 1999. PMID: 10411485
26 results