Laine K - Search Results

1

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation.

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. Rautio J, et al. Among authors: laine k. Eur J Pharm Sci. 2000 Aug;11(2):157-63. doi: 10.1016/s0928-0987(00)00090-7. Eur J Pharm Sci. 2000. PMID: 10915963

2

Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide.

Juntunen J, Huuskonen J, Laine K, Niemi R, Taipale H, Nevalainen T, Pate DW, Järvinen T. Juntunen J, et al. Among authors: laine k. Eur J Pharm Sci. 2003 May;19(1):37-43. doi: 10.1016/s0928-0987(03)00044-7. Eur J Pharm Sci. 2003. PMID: 12729860

3

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin.

Huttunen KM, Leppänen J, Laine K, Vepsäläinen J, Rautio J. Huttunen KM, et al. Among authors: laine k. Eur J Pharm Sci. 2013 Jul 16;49(4):624-8. doi: 10.1016/j.ejps.2013.05.023. Epub 2013 Jun 1. Eur J Pharm Sci. 2013. PMID: 23732628

4

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (Naproxen) for topical drug delivery.

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. Rautio J, et al. Among authors: laine k. J Med Chem. 2000 Apr 20;43(8):1489-94. doi: 10.1021/jm991149s. J Med Chem. 2000. PMID: 10780905

5

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether.

Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T. Juntunen J, et al. Among authors: laine k. J Med Chem. 2003 Nov 6;46(23):5083-6. doi: 10.1021/jm030877j. J Med Chem. 2003. PMID: 14584958

6

Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs.

Niemi R, Huuskonen J, Laine K, Järvinen T. Niemi R, et al. Among authors: laine k. Int J Pharm. 2005 May 13;295(1-2):121-7. doi: 10.1016/j.ijpharm.2005.02.002. Int J Pharm. 2005. PMID: 15847997

7

Prodrug approaches for CNS delivery.

Rautio J, Laine K, Gynther M, Savolainen J. Rautio J, et al. Among authors: laine k. AAPS J. 2008;10(1):92-102. doi: 10.1208/s12248-008-9009-8. Epub 2008 Feb 5. AAPS J. 2008. PMID: 18446509 Free PMC article. Review.

8

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J. Huttunen KM, et al. Among authors: laine k. J Med Chem. 2009 Jul 23;52(14):4142-8. doi: 10.1021/jm900274q. J Med Chem. 2009. PMID: 19522462

9

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor.

Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J, Sairanen M. Rautio J, et al. Among authors: laine k. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2614-6. doi: 10.1016/j.bmcl.2010.02.057. Epub 2010 Feb 19. Bioorg Med Chem Lett. 2010. PMID: 20231095

10

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

Huttunen KM, Leppänen J, Vepsäläinen J, Sirviö J, Laine K, Rautio J. Huttunen KM, et al. Among authors: laine k. J Pharm Sci. 2012 Aug;101(8):2854-60. doi: 10.1002/jps.23221. Epub 2012 May 30. J Pharm Sci. 2012. PMID: 22648910

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