Lomas DA - Search Results

1

Pathogenic alpha 1-antitrypsin polymers are formed by reactive loop-beta-sheet A linkage.

Sivasothy P, Dafforn TR, Gettins PG, Lomas DA. Sivasothy P, et al. Among authors: lomas da. J Biol Chem. 2000 Oct 27;275(43):33663-8. doi: 10.1074/jbc.M004054200. J Biol Chem. 2000. PMID: 10924508 Free article.

2

A kinetic mechanism for the polymerization of alpha1-antitrypsin.

Dafforn TR, Mahadeva R, Elliott PR, Sivasothy P, Lomas DA. Dafforn TR, et al. Among authors: lomas da. J Biol Chem. 1999 Apr 2;274(14):9548-55. doi: 10.1074/jbc.274.14.9548. J Biol Chem. 1999. PMID: 10092640 Free article.

3

Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis.

Mahadeva R, Chang WS, Dafforn TR, Oakley DJ, Foreman RC, Calvin J, Wight DG, Lomas DA. Mahadeva R, et al. Among authors: lomas da. J Clin Invest. 1999 Apr;103(7):999-1006. doi: 10.1172/JCI4874. J Clin Invest. 1999. PMID: 10194472 Free PMC article.

4

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.

Gooptu B, Hazes B, Chang WS, Dafforn TR, Carrell RW, Read RJ, Lomas DA. Gooptu B, et al. Among authors: lomas da. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):67-72. doi: 10.1073/pnas.97.1.67. Proc Natl Acad Sci U S A. 2000. PMID: 10618372 Free PMC article.

5

Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease.

Elliott PR, Pei XY, Dafforn TR, Lomas DA. Elliott PR, et al. Among authors: lomas da. Protein Sci. 2000 Jul;9(7):1274-81. doi: 10.1110/ps.9.7.1274. Protein Sci. 2000. PMID: 10933492 Free PMC article.

6

Polymerization of plasminogen activator inhibitor-1.

Zhou A, Faint R, Charlton P, Dafforn TR, Carrell RW, Lomas DA. Zhou A, et al. Among authors: lomas da. J Biol Chem. 2001 Mar 23;276(12):9115-22. doi: 10.1074/jbc.M010631200. Epub 2000 Dec 1. J Biol Chem. 2001. PMID: 11102455 Free article.

7

alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.

Lomas DA, Elliott PR, Sidhar SK, Foreman RC, Finch JT, Cox DW, Whisstock JC, Carrell RW. Lomas DA, et al. J Biol Chem. 1995 Jul 14;270(28):16864-70. doi: 10.1074/jbc.270.28.16864. J Biol Chem. 1995. PMID: 7622502 Free article.

8

Preparation and characterization of latent alpha 1-antitrypsin.

Lomas DA, Elliott PR, Chang WS, Wardell MR, Carrell RW. Lomas DA, et al. J Biol Chem. 1995 Mar 10;270(10):5282-8. doi: 10.1074/jbc.270.10.5282. J Biol Chem. 1995. PMID: 7890640 Free article.

9

Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization.

Lomas DA, Finch JT, Seyama K, Nukiwa T, Carrell RW. Lomas DA, et al. J Biol Chem. 1993 Jul 25;268(21):15333-5. J Biol Chem. 1993. PMID: 8340361 Free article.

10

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.

Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. Silverman GA, et al. Among authors: lomas da. J Biol Chem. 2001 Sep 7;276(36):33293-6. doi: 10.1074/jbc.R100016200. Epub 2001 Jul 2. J Biol Chem. 2001. PMID: 11435447 Free article. Review. No abstract available.

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