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The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.
Pagano A, Ruegg D, Litschig S, Stoehr N, Stierlin C, Heinrich M, Floersheim P, Prezèau L, Carroll F, Pin JP, Cambria A, Vranesic I, Flor PJ, Gasparini F, Kuhn R. Pagano A, et al. Among authors: stierlin c. J Biol Chem. 2000 Oct 27;275(43):33750-8. doi: 10.1074/jbc.M006230200. J Biol Chem. 2000. PMID: 10934211 Free article.