Nnane IP - Search Results

1

Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids.

Njar VC, Nnane IP, Brodie AM. Njar VC, et al. Among authors: nnane ip. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1905-8. doi: 10.1016/s0960-894x(00)00391-7. Bioorg Med Chem Lett. 2000. PMID: 10987414

2

Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.

Njar VC, Kato K, Nnane IP, Grigoryev DN, Long BJ, Brodie AM. Njar VC, et al. Among authors: nnane ip. J Med Chem. 1998 Mar 12;41(6):902-12. doi: 10.1021/jm970568r. J Med Chem. 1998. PMID: 9526564

3

Synthesis and in vitro activity of some epimeric 20 alpha-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17 alpha-hydroxylase/C17,20-lyase and 5 alpha-reductase.

Ling YZ, Li JS, Kato K, Liu Y, Wang X, Klus GT, Marat K, Nnane IP, Brodie AM. Ling YZ, et al. Among authors: nnane ip. Bioorg Med Chem. 1998 Oct;6(10):1683-93. doi: 10.1016/s0968-0896(98)00110-2. Bioorg Med Chem. 1998. PMID: 9839000

4

Effects of novel 17-azolyl compounds on androgen synthesis in vitro and in vivo.

Nnane IP, Njar VC, Liu Y, Lu Q, Brodie AM. Nnane IP, et al. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):145-52. doi: 10.1016/s0960-0760(99)00129-6. J Steroid Biochem Mol Biol. 1999. PMID: 10659703

5

Quantification of a novel retinoic acid metabolism inhibitor, 4-(1H-imidazol-1-yl)retinoic acid (VN/14-1RA) and other retinoids in rat plasma by liquid chromatography with diode-array detection.

Wu C, Njar V, Brodie A, Borenstein M, Nnane I. Wu C, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Oct 25;810(2):203-8. doi: 10.1016/j.jchromb.2004.07.028. J Chromatogr B Analyt Technol Biomed Life Sci. 2004. PMID: 15380716

6

Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model.

Handratta VD, Jelovac D, Long BJ, Kataria R, Nnane IP, Njar VC, Brodie AM. Handratta VD, et al. Among authors: nnane ip. J Steroid Biochem Mol Biol. 2004 Oct;92(3):155-65. doi: 10.1016/j.jsbmb.2004.07.006. J Steroid Biochem Mol Biol. 2004. PMID: 15555909

7

Effects of some novel inhibitors of C17,20-lyase and 5alpha-reductase in vitro and in vivo and their potential role in the treatment of prostate cancer.

Nnane IP, Kato K, Liu Y, Lu Q, Wang X, Ling YZ, Brodie A. Nnane IP, et al. Cancer Res. 1998 Sep 1;58(17):3826-32. Cancer Res. 1998. PMID: 9731491

8

Inhibition of androgen synthesis in human testicular and prostatic microsomes and in male rats by novel steroidal compounds.

Nnane IP, Kato K, Liu Y, Long BJ, Lu Q, Wang X, Ling YZ, Brodie A. Nnane IP, et al. Endocrinology. 1999 Jun;140(6):2891-7. doi: 10.1210/endo.140.6.6832. Endocrinology. 1999. PMID: 10342882

9

Effects of new 17alpha-hydroxylase/C(17,20)-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo.

Grigoryev DN, Long BJ, Nnane IP, Njar VC, Liu Y, Brodie AM. Grigoryev DN, et al. Among authors: nnane ip. Br J Cancer. 1999 Oct;81(4):622-30. doi: 10.1038/sj.bjc.6690739. Br J Cancer. 1999. PMID: 10574247 Free PMC article.

10

Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis.

Nnane IP, Long BJ, Ling YZ, Grigoryev DN, Brodie AM. Nnane IP, et al. Br J Cancer. 2000 Jul;83(1):74-82. doi: 10.1054/bjoc.2000.1136. Br J Cancer. 2000. PMID: 10883671 Free PMC article.

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