Thomas A - Search Results

1

Bcl-2 and bax expression and chlorambucil-induced apoptosis in the T-cells and leukaemic B-cells of untreated B-cell chronic lymphocytic leukaemia patients.

Thomas A, Pepper C, Hoy T, Bentley P. Thomas A, et al. Leuk Res. 2000 Oct;24(10):813-21. doi: 10.1016/s0145-2126(00)00051-5. Leuk Res. 2000. PMID: 10996199

2

Retinoid-induced apoptosis in B-cell chronic lymphocytic leukaemia cells is mediated through caspase-3 activation and is independent of p53, the retinoic acid receptor, and differentiation.

Pepper C, Ali K, Thomas A, Hoy T, Fegan C, Chowdary P, Kell J, Bentley P. Pepper C, et al. Among authors: thomas a. Eur J Haematol. 2002 Oct;69(4):227-35. doi: 10.1034/j.1600-0609.2002.02799.x. Eur J Haematol. 2002. PMID: 12431242

3

The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro.

Pepper C, Thomas A, Hoy T, Milligan D, Bentley P, Fegan C. Pepper C, et al. Among authors: thomas a. Blood. 2003 Apr 1;101(7):2454-60. doi: 10.1182/blood-2002-07-1984. Epub 2002 Nov 21. Blood. 2003. PMID: 12446453 Free article.

4

Antisense oligonucleotides complementary to Bax transcripts reduce the susceptibility of B-cell chronic lymphocytic leukaemia cells to apoptosis in a bcl-2 independent manner.

Pepper C, Thomas A, Hoy T, Bentley P. Pepper C, et al. Among authors: thomas a. Leuk Lymphoma. 2002 Oct;43(10):2003-9. doi: 10.1080/1042819021000015961. Leuk Lymphoma. 2002. PMID: 12481899

5

Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.

Pepper C, Thomas A, Fegan C, Hoy T, Bentley P. Pepper C, et al. Among authors: thomas a. Leuk Lymphoma. 2003 Feb;44(2):337-42. doi: 10.1080/1042819021000029984. Leuk Lymphoma. 2003. PMID: 12688354

6

Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.

Pepper C, Thomas A, Hoy T, Tighe J, Culligan D, Fegan C, Bentley P. Pepper C, et al. Among authors: thomas a. Cell Cycle. 2003 Jan-Feb;2(1):53-8. Cell Cycle. 2003. PMID: 12695689

7

Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells.

Thomas A, Pepper C, Hoy T, Bentley P. Thomas A, et al. Leuk Lymphoma. 2004 May;45(5):997-1008. doi: 10.1080/10428190310001639470. Leuk Lymphoma. 2004. PMID: 15291360

8

Failure to induce resistance to cytotoxic drugs in normal lymphocytes.

Bentley P, Thomas A, Thomas J. Bentley P, et al. Among authors: thomas j, thomas a. Leuk Res. 1996 Aug;20(8):645-8. doi: 10.1016/0145-2126(96)00024-0. Leuk Res. 1996. PMID: 8913317 Clinical Trial.

9

Flow cytometric assessment of three different methods for the measurement of in vitro apoptosis.

Pepper C, Thomas A, Tucker H, Hoy T, Bentley P. Pepper C, et al. Among authors: thomas a. Leuk Res. 1998 May;22(5):439-44. doi: 10.1016/s0145-2126(98)00013-7. Leuk Res. 1998. PMID: 9652730

10

Chlorambucil resistance in B-cell chronic lymphocytic leukaemia is mediated through failed Bax induction and selection of high Bcl-2-expressing subclones.

Pepper C, Thomas A, Hoy T, Bentley P. Pepper C, et al. Among authors: thomas a. Br J Haematol. 1999 Mar;104(3):581-8. doi: 10.1046/j.1365-2141.1999.01210.x. Br J Haematol. 1999. PMID: 10086798 Free article.

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