Balzarini J - Search Results

1

A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T.

Knaggs MH, McGuigan C, Harris SA, Heshmati P, Cahard D, Gilbert IH, Balzarini J. Knaggs MH, et al. Among authors: balzarini j. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2075-8. doi: 10.1016/s0960-894x(00)00397-8. Bioorg Med Chem Lett. 2000. PMID: 10999474

2

Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.

McGuigan C, Harris SA, Daluge SM, Gudmundsson KS, McLean EW, Burnette TC, Marr H, Hazen R, Condreay LD, Johnson L, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: balzarini j. J Med Chem. 2005 May 19;48(10):3504-15. doi: 10.1021/jm0491400. J Med Chem. 2005. PMID: 15887959

3

Design, synthesis, and anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U), 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

Mehellou Y, McGuigan C, Brancale A, Balzarini J. Mehellou Y, et al. Among authors: balzarini j. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3666-9. doi: 10.1016/j.bmcl.2007.04.043. Epub 2007 Apr 22. Bioorg Med Chem Lett. 2007. PMID: 17485204

4

Successful kinase bypass with new acyclovir phosphoramidate prodrugs.

McGuigan C, Derudas M, Bugert JJ, Andrei G, Snoeck R, Balzarini J. McGuigan C, et al. Among authors: balzarini j. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4364-7. doi: 10.1016/j.bmcl.2008.06.069. Epub 2008 Jun 24. Bioorg Med Chem Lett. 2008. PMID: 18614365

5

An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

Mehellou Y, Balzarini J, McGuigan C. Mehellou Y, et al. Among authors: balzarini j. Org Biomol Chem. 2009 Jun 21;7(12):2548-53. doi: 10.1039/b904276h. Epub 2009 Apr 30. Org Biomol Chem. 2009. PMID: 19503928

6

The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.

Derudas M, Carta D, Brancale A, Vanpouille C, Lisco A, Margolis L, Balzarini J, McGuigan C. Derudas M, et al. Among authors: balzarini j. J Med Chem. 2009 Sep 10;52(17):5520-30. doi: 10.1021/jm9007856. J Med Chem. 2009. PMID: 19645484 Free PMC article.

7

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin.

Derudas M, Brancale A, Naesens L, Neyts J, Balzarini J, McGuigan C. Derudas M, et al. Among authors: balzarini j. Bioorg Med Chem. 2010 Apr 1;18(7):2748-55. doi: 10.1016/j.bmc.2010.02.015. Epub 2010 Feb 15. Bioorg Med Chem. 2010. PMID: 20207546 Free PMC article.

8

Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.

Quintiliani M, Persoons L, Solaroli N, Karlsson A, Andrei G, Snoeck R, Balzarini J, McGuigan C. Quintiliani M, et al. Among authors: balzarini j. Bioorg Med Chem. 2011 Jul 15;19(14):4338-45. doi: 10.1016/j.bmc.2011.05.037. Epub 2011 May 27. Bioorg Med Chem. 2011. PMID: 21696963 Free PMC article.

9

Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads.

Hamon N, Slusarczyk M, Serpi M, Balzarini J, McGuigan C. Hamon N, et al. Among authors: balzarini j. Bioorg Med Chem. 2015 Feb 15;23(4):829-38. doi: 10.1016/j.bmc.2014.12.039. Epub 2014 Dec 25. Bioorg Med Chem. 2015. PMID: 25616343 Free PMC article.

10

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

McGuigan C, Cahard D, Sheeka HM, De Clercq E, Balzarini J. McGuigan C, et al. Among authors: balzarini j. J Med Chem. 1996 Apr 12;39(8):1748-53. doi: 10.1021/jm950605j. J Med Chem. 1996. PMID: 8648614

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