Markwalder JA - Search Results

1

The species-dependent metabolism of efavirenz produces a nephrotoxic glutathione conjugate in rats.

Mutlib AE, Gerson RJ, Meunier PC, Haley PJ, Chen H, Gan LS, Davies MH, Gemzik B, Christ DD, Krahn DF, Markwalder JA, Seitz SP, Robertson RT, Miwa GT. Mutlib AE, et al. Among authors: markwalder ja. Toxicol Appl Pharmacol. 2000 Nov 15;169(1):102-13. doi: 10.1006/taap.2000.9055. Toxicol Appl Pharmacol. 2000. PMID: 11076702

2

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al. Lam PY, et al. Among authors: markwalder ja. J Med Chem. 1996 Aug 30;39(18):3514-25. doi: 10.1021/jm9602571. J Med Chem. 1996. PMID: 8784449

3

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.

Patel M, Ko SS, McHugh RJ Jr, Markwalder JA, Srivastava AS, Cordova BC, Klabe RM, Erickson-Viitanen S, Trainor GL, Seitz SP. Patel M, et al. Among authors: markwalder ja. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2805-10. doi: 10.1016/s0960-894x(99)00486-2. Bioorg Med Chem Lett. 1999. PMID: 10522695

4

Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz.

Mutlib AE, Chen H, Nemeth GA, Markwalder JA, Seitz SP, Gan LS, Christ DD. Mutlib AE, et al. Among authors: markwalder ja. Drug Metab Dispos. 1999 Nov;27(11):1319-33. Drug Metab Dispos. 1999. PMID: 10534318

5

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.

Markwalder JA, Christ DD, Mutlib A, Cordova BC, Klabe RM, Seitz SP. Markwalder JA, et al. Bioorg Med Chem Lett. 2001 Mar 12;11(5):619-22. doi: 10.1016/s0960-894x(01)00012-9. Bioorg Med Chem Lett. 2001. PMID: 11266155

6

Identification of selective inhibitors of cyclin dependent kinase 4.

Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM. Carini DJ, et al. Among authors: markwalder ja. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2209-11. doi: 10.1016/s0960-894x(01)00416-4. Bioorg Med Chem Lett. 2001. PMID: 11514172

7

A kinetic characterization of the glycosyltransferase activity of Eschericia coli PBP1b and development of a continuous fluorescence assay.

Schwartz B, Markwalder JA, Seitz SP, Wang Y, Stein RL. Schwartz B, et al. Among authors: markwalder ja. Biochemistry. 2002 Oct 15;41(41):12552-61. doi: 10.1021/bi026205x. Biochemistry. 2002. PMID: 12369847

8

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.

Yue EW, DiMeo SV, Higley CA, Markwalder JA, Burton CR, Benfield PA, Grafstrom RH, Cox S, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Trainor GL, Seitz SP. Yue EW, et al. Among authors: markwalder ja. Bioorg Med Chem Lett. 2004 Jan 19;14(2):343-6. doi: 10.1016/j.bmcl.2003.11.008. Bioorg Med Chem Lett. 2004. PMID: 14698155

9

Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors.

Rossi KA, Markwalder JA, Seitz SP, Chang CH, Cox S, Boisclair MD, Brizuela L, Brenner SL, Stouten PF. Rossi KA, et al. Among authors: markwalder ja. J Comput Aided Mol Des. 2005 Feb;19(2):111-22. doi: 10.1007/s10822-005-1778-x. J Comput Aided Mol Des. 2005. PMID: 16075305

10

Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors.

Markwalder JA, Seitz SP, Blat Y, Elkin L, Hunt JT, Pabalan JG, Jure-Kunkel MN, Vite GD, Covello K. Markwalder JA, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):582-585. doi: 10.1016/j.bmcl.2016.12.015. Epub 2016 Dec 7. Bioorg Med Chem Lett. 2017. PMID: 28003141

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