Borthwick AD - Search Results

1

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template.

Borthwick AD, Angier SJ, Crame AJ, Exall AM, Haley TM, Hart GJ, Mason AM, Pennell AM, Weingarten GG. Borthwick AD, et al. J Med Chem. 2000 Nov 16;43(23):4452-64. doi: 10.1021/jm000078q. J Med Chem. 2000. PMID: 11087570

2

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.

Borthwick AD, Crame AJ, Ertl PF, Exall AM, Haley TM, Hart GJ, Mason AM, Pennell AM, Singh OM, Weingarten GG, Woolven JM. Borthwick AD, et al. J Med Chem. 2002 Jan 3;45(1):1-18. doi: 10.1021/jm0102203. J Med Chem. 2002. PMID: 11754575

3

Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability.

Borthwick AD, Exall AM, Haley TM, Jackson DL, Mason AM, Weingarten GG. Borthwick AD, et al. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1719-22. doi: 10.1016/s0960-894x(02)00294-9. Bioorg Med Chem Lett. 2002. PMID: 12067545

4

Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.

Borthwick AD, Davies DE, Ertl PF, Exall AM, Haley TM, Hart GJ, Jackson DL, Parry NR, Patikis A, Trivedi N, Weingarten GG, Woolven JM. Borthwick AD, et al. J Med Chem. 2003 Oct 9;46(21):4428-49. doi: 10.1021/jm030810w. J Med Chem. 2003. PMID: 14521407

5

Synthesis of benzodioxinopyrroles as selective alpha 2-adrenoceptor antagonists.

Kitchin J, Borthwick AD, Brodie AC, Cherry PC, Crame AJ, Pipe AJ, Procopiou PA, Seaman MA, Turnbull JP. Kitchin J, et al. Among authors: borthwick ad. Bioorg Med Chem. 1995 Dec;3(12):1595-603. doi: 10.1016/0968-0896(95)00143-3. Bioorg Med Chem. 1995. PMID: 8770384

6

Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.

Borthwick AD, Weingarten G, Haley TM, Tomaszewski M, Wang W, Hu Z, Bedard J, Jin H, Yuen L, Mansour TS. Borthwick AD, et al. Bioorg Med Chem Lett. 1998 Feb 17;8(4):365-70. doi: 10.1016/s0960-894x(98)00032-8. Bioorg Med Chem Lett. 1998. PMID: 9871686

7

Investigation of the covalent modification of the catalytic triad of human cytomegalovirus protease by pseudo-reversible beta-lactam inhibitors and a peptide chloromethylketone.

Haley TM, Angier SJ, Borthwick AD, Montgomery DS, Purvis IJ, Smart DH, Bessant C, Van Wely C, Hart GJ. Haley TM, et al. Among authors: borthwick ad. J Mass Spectrom. 1998 Dec;33(12):1246-55. doi: 10.1002/(SICI)1096-9888(199812)33:12<1246::AID-JMS743>3.0.CO;2-E. J Mass Spectrom. 1998. PMID: 9875526

8

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR.

Wyatt PG, Allen MJ, Borthwick AD, Davies DE, Exall AM, Hatley RJ, Irving WR, Livermore DG, Miller ND, Nerozzi F, Sollis SL, Szardenings AK. Wyatt PG, et al. Among authors: borthwick ad. Bioorg Med Chem Lett. 2005 May 16;15(10):2579-82. doi: 10.1016/j.bmcl.2005.03.045. Bioorg Med Chem Lett. 2005. PMID: 15863320

9

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics.

Borthwick AD, Davies DE, Exall AM, Livermore DG, Sollis SL, Nerozzi F, Allen MJ, Perren M, Shabbir SS, Woollard PM, Wyatt PG. Borthwick AD, et al. J Med Chem. 2005 Nov 3;48(22):6956-69. doi: 10.1021/jm050557v. J Med Chem. 2005. PMID: 16250654

10

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.

Borthwick AD, Davies DE, Exall AM, Hatley RJ, Hughes JA, Irving WR, Livermore DG, Sollis SL, Nerozzi F, Valko KL, Allen MJ, Perren M, Shabbir SS, Woollard PM, Price MA. Borthwick AD, et al. J Med Chem. 2006 Jul 13;49(14):4159-70. doi: 10.1021/jm060073e. J Med Chem. 2006. PMID: 16821776

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