Brodie AM - Search Results

1

Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer.

Long BJ, Grigoryev DN, Nnane IP, Liu Y, Ling YZ, Brodie AM. Long BJ, et al. Among authors: brodie am. Cancer Res. 2000 Dec 1;60(23):6630-40. Cancer Res. 2000. PMID: 11118046

2

Growth inhibition of human prostate cells in vitro by novel inhibitors of androgen synthesis.

Klus GT, Nakamura J, Li JS, Ling YZ, Son C, Kemppainen JA, Wilson EM, Brodie AM. Klus GT, et al. Among authors: brodie am. Cancer Res. 1996 Nov 1;56(21):4956-64. Cancer Res. 1996. PMID: 8895750

3

Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.

Njar VC, Kato K, Nnane IP, Grigoryev DN, Long BJ, Brodie AM. Njar VC, et al. Among authors: brodie am. J Med Chem. 1998 Mar 12;41(6):902-12. doi: 10.1021/jm970568r. J Med Chem. 1998. PMID: 9526564

4

Synthesis and in vitro activity of some epimeric 20 alpha-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17 alpha-hydroxylase/C17,20-lyase and 5 alpha-reductase.

Ling YZ, Li JS, Kato K, Liu Y, Wang X, Klus GT, Marat K, Nnane IP, Brodie AM. Ling YZ, et al. Among authors: brodie am. Bioorg Med Chem. 1998 Oct;6(10):1683-93. doi: 10.1016/s0968-0896(98)00110-2. Bioorg Med Chem. 1998. PMID: 9839000

5

Cytochrome P450c17-expressing Escherichia coli as a first-step screening system for 17alpha-hydroxylase-C17,20-lyase inhibitors.

Grigoryev DN, Kato K, Njar VC, Long BJ, Ling YZ, Wang X, Mohler J, Brodie AM. Grigoryev DN, et al. Among authors: brodie am. Anal Biochem. 1999 Feb 15;267(2):319-30. doi: 10.1006/abio.1998.2993. Anal Biochem. 1999. PMID: 10036137

6

Effects of new 17alpha-hydroxylase/C(17,20)-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo.

Grigoryev DN, Long BJ, Nnane IP, Njar VC, Liu Y, Brodie AM. Grigoryev DN, et al. Among authors: brodie am. Br J Cancer. 1999 Oct;81(4):622-30. doi: 10.1038/sj.bjc.6690739. Br J Cancer. 1999. PMID: 10574247 Free PMC article.

7

Effects of novel 17-azolyl compounds on androgen synthesis in vitro and in vivo.

Nnane IP, Njar VC, Liu Y, Lu Q, Brodie AM. Nnane IP, et al. Among authors: brodie am. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):145-52. doi: 10.1016/s0960-0760(99)00129-6. J Steroid Biochem Mol Biol. 1999. PMID: 10659703

8

Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis.

Nnane IP, Long BJ, Ling YZ, Grigoryev DN, Brodie AM. Nnane IP, et al. Among authors: brodie am. Br J Cancer. 2000 Jul;83(1):74-82. doi: 10.1054/bjoc.2000.1136. Br J Cancer. 2000. PMID: 10883671 Free PMC article.

9

Effects of exemestane and tamoxifen in a postmenopausal breast cancer model.

Jelovac D, Macedo L, Handratta V, Long BJ, Goloubeva OG, Ingle JN, Brodie AM. Jelovac D, et al. Among authors: brodie am. Clin Cancer Res. 2004 Nov 1;10(21):7375-81. doi: 10.1158/1078-0432.CCR-04-0565. Clin Cancer Res. 2004. PMID: 15534114

10

Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model.

Handratta VD, Jelovac D, Long BJ, Kataria R, Nnane IP, Njar VC, Brodie AM. Handratta VD, et al. Among authors: brodie am. J Steroid Biochem Mol Biol. 2004 Oct;92(3):155-65. doi: 10.1016/j.jsbmb.2004.07.006. J Steroid Biochem Mol Biol. 2004. PMID: 15555909

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