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Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity.
Tamamura H, Sugioka M, Odagaki Y, Omagari A, Kan Y, Oishi S, Nakashima H, Yamamoto N, Peiper SC, Hamanaka N, Otaka A, Fujii N. Tamamura H, et al. Among authors: yamamoto n. Bioorg Med Chem Lett. 2001 Feb 12;11(3):359-62. doi: 10.1016/s0960-894x(00)00664-8. Bioorg Med Chem Lett. 2001. PMID: 11212110
Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.
Tamamura H, Omagari A, Hiramatsu K, Gotoh K, Kanamoto T, Xu Y, Kodama E, Matsuoka M, Hattori T, Yamamoto N, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: yamamoto n. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1897-902. doi: 10.1016/s0960-894x(01)00323-7. Bioorg Med Chem Lett. 2001. PMID: 11459656
Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr(5,12),Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection.
Tamamura H, Imai M, Ishihara T, Masuda M, Funakoshi H, Oyake H, Murakami T, Arakaki R, Nakashima H, Otaka A, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N. Tamamura H, et al. Among authors: yamamoto n. Bioorg Med Chem. 1998 Jul;6(7):1033-41. doi: 10.1016/s0968-0896(98)00061-3. Bioorg Med Chem. 1998. PMID: 9730240
Synthesis and anti-HIV activity of nonatyrosine N- and O1-9-decasulfate.
Ueki M, Watanabe S, Ishii Y, Okunaka O, Uchino K, Saitoh T, Higashi K, Nakashima H, Yamamoto N, Ogawara H. Ueki M, et al. Among authors: yamamoto n. Bioorg Med Chem. 2001 Feb;9(2):477-86. doi: 10.1016/s0968-0896(00)00269-8. Bioorg Med Chem. 2001. PMID: 11249139
6,367 results