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Page 1
Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators.
Matsoukas J, Apostolopoulos V, Kalbacher H, Papini AM, Tselios T, Chatzantoni K, Biagioli T, Lolli F, Deraos S, Papathanassopoulos P, Troganis A, Mantzourani E, Mavromoustakos T, Mouzaki A. Matsoukas J, et al. Among authors: mouzaki a. J Med Chem. 2005 Mar 10;48(5):1470-80. doi: 10.1021/jm040849g. J Med Chem. 2005. PMID: 15743189
Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease.
Deraos G, Chatzantoni K, Matsoukas MT, Tselios T, Deraos S, Katsara M, Papathanasopoulos P, Vynios D, Apostolopoulos V, Mouzaki A, Matsoukas J. Deraos G, et al. Among authors: mouzaki a. J Med Chem. 2008 Dec 25;51(24):7834-42. doi: 10.1021/jm800891n. J Med Chem. 2008. PMID: 19053745
Properties of myelin altered peptide ligand cyclo(87-99)(Ala91,Ala96)MBP87-99 render it a promising drug lead for immunotherapy of multiple sclerosis.
Deraos G, Rodi M, Kalbacher H, Chatzantoni K, Karagiannis F, Synodinos L, Plotas P, Papalois A, Dimisianos N, Papathanasopoulos P, Gatos D, Tselios T, Apostolopoulos V, Mouzaki A, Matsoukas J. Deraos G, et al. Among authors: mouzaki a. Eur J Med Chem. 2015 Aug 28;101:13-23. doi: 10.1016/j.ejmech.2015.06.015. Epub 2015 Jun 17. Eur J Med Chem. 2015. PMID: 26112377
149 results