Roberts GC - Search Results

1

Engineering of a functional human NADH-dependent cytochrome P450 system.

Döhr O, Paine MJ, Friedberg T, Roberts GC, Wolf CR. Döhr O, et al. Among authors: roberts gc. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):81-6. doi: 10.1073/pnas.98.1.81. Proc Natl Acad Sci U S A. 2001. PMID: 11136248 Free PMC article.

2

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

Flanagan JU, McLaughlin LA, Paine MJ, Sutcliffe MJ, Roberts GC, Wolf CR. Flanagan JU, et al. Among authors: roberts gc. Biochem J. 2003 Mar 15;370(Pt 3):921-6. doi: 10.1042/BJ20021841. Biochem J. 2003. PMID: 12482324 Free PMC article.

3

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

McLaughlin LA, Paine MJ, Kemp CA, Maréchal JD, Flanagan JU, Ward CJ, Sutcliffe MJ, Roberts GC, Wolf CR. McLaughlin LA, et al. Among authors: roberts gc. J Biol Chem. 2005 Nov 18;280(46):38617-24. doi: 10.1074/jbc.M505974200. Epub 2005 Sep 14. J Biol Chem. 2005. PMID: 16162505 Free article.

4

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.

Modi S, Paine MJ, Sutcliffe MJ, Lian LY, Primrose WU, Wolf CR, Roberts GC. Modi S, et al. Among authors: roberts gc. Biochemistry. 1996 Apr 9;35(14):4540-50. doi: 10.1021/bi952742o. Biochemistry. 1996. PMID: 8605204

5

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

Paine MJ, Gilham D, Roberts GC, Wolf CR. Paine MJ, et al. Among authors: roberts gc. Arch Biochem Biophys. 1996 Apr 1;328(1):143-50. doi: 10.1006/abbi.1996.0154. Arch Biochem Biophys. 1996. PMID: 8638923

6

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.

Smith G, Modi S, Pillai I, Lian LY, Sutcliffe MJ, Pritchard MP, Friedberg T, Roberts GC, Wolf CR. Smith G, et al. Among authors: roberts gc. Biochem J. 1998 May 1;331 ( Pt 3)(Pt 3):783-92. doi: 10.1042/bj3310783. Biochem J. 1998. PMID: 9560305 Free PMC article.

7

Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity.

Paine MJ, Ayivor S, Munro A, Tsan P, Lian LY, Roberts GC, Wolf CR. Paine MJ, et al. Among authors: roberts gc. Biochemistry. 2001 Nov 13;40(45):13439-47. doi: 10.1021/bi011147l. Biochemistry. 2001. PMID: 11695890

8

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

Gutierrez A, Paine M, Wolf CR, Scrutton NS, Roberts GC. Gutierrez A, et al. Among authors: roberts gc. Biochemistry. 2002 Apr 9;41(14):4626-37. doi: 10.1021/bi0159433. Biochemistry. 2002. PMID: 11926825

9

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Paine MJ, McLaughlin LA, Flanagan JU, Kemp CA, Sutcliffe MJ, Roberts GC, Wolf CR. Paine MJ, et al. Among authors: roberts gc. J Biol Chem. 2003 Feb 7;278(6):4021-7. doi: 10.1074/jbc.M209519200. Epub 2002 Nov 22. J Biol Chem. 2003. PMID: 12446689 Free article.

10

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Flanagan JU, Maréchal JD, Ward R, Kemp CA, McLaughlin LA, Sutcliffe MJ, Roberts GC, Paine MJ, Wolf CR. Flanagan JU, et al. Among authors: roberts gc. Biochem J. 2004 Jun 1;380(Pt 2):353-60. doi: 10.1042/BJ20040062. Biochem J. 2004. PMID: 14992686 Free PMC article.

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