Vacca JP - Search Results

1

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

Wai JS, Egbertson MS, Payne LS, Fisher TE, Embrey MW, Tran LO, Melamed JY, Langford HM, Guare JP Jr, Zhuang L, Grey VE, Vacca JP, Holloway MK, Naylor-Olsen AM, Hazuda DJ, Felock PJ, Wolfe AL, Stillmock KA, Schleif WA, Gabryelski LJ, Young SD. Wai JS, et al. Among authors: vacca jp. J Med Chem. 2000 Dec 28;43(26):4923-6. doi: 10.1021/jm000176b. J Med Chem. 2000. PMID: 11150161 No abstract available.

2

Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.

Darke PL, Kohl NE, Hanobik MG, Leu CT, Vacca JP, Guare JP, Heimbach JC, Dixon RA. Darke PL, et al. Among authors: vacca jp. Adv Exp Med Biol. 1991;306:483-7. doi: 10.1007/978-1-4684-6012-4_61. Adv Exp Med Biol. 1991. PMID: 1812746 No abstract available.

3

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al. deSolms SJ, et al. Among authors: vacca jp. J Med Chem. 1991 Sep;34(9):2852-7. doi: 10.1021/jm00113a025. J Med Chem. 1991. PMID: 1910089

4

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

Vacca JP, Guare JP, deSolms SJ, Sanders WM, Giuliani EA, Young SD, Darke PL, Zugay J, Sigal IS, Schleif WA, et al. Vacca JP, et al. J Med Chem. 1991 Mar;34(3):1225-8. doi: 10.1021/jm00107a050. J Med Chem. 1991. PMID: 2002465 No abstract available.

5

Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.

Huff JR, Baldwin JJ, deSolms SJ, Guare JP Jr, Hunt CA, Randall WC, Sanders WS, Smith SJ, Vacca JP, Zrada MM. Huff JR, et al. Among authors: vacca jp. J Med Chem. 1988 Mar;31(3):641-5. doi: 10.1021/jm00398a025. J Med Chem. 1988. PMID: 2831365

6

Metabolism of synthetic inositol trisphosphate analogs.

Polokoff MA, Bencen GH, Vacca JP, deSolms SJ, Young SD, Huff JR. Polokoff MA, et al. Among authors: vacca jp. J Biol Chem. 1988 Aug 25;263(24):11922-7. J Biol Chem. 1988. PMID: 2841338 Free article.

7

[3H]L-654,284 as a probe of the central alpha 2 adrenoceptor.

Randall WC, Huff JR, Vacca JP, Guare JP, Chen R, Rosegay A, Baldwin JJ. Randall WC, et al. Among authors: vacca jp. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jul;338(1):47-52. doi: 10.1007/BF00168811. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2907099

8

N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.

Huff JR, Anderson PS, Baldwin JJ, Clineschmidt BV, Guare JP, Lotti VJ, Pettibone DJ, Randall WC, Vacca JP. Huff JR, et al. Among authors: vacca jp. J Med Chem. 1985 Dec;28(12):1756-9. doi: 10.1021/jm00150a002. J Med Chem. 1985. PMID: 2999400 No abstract available.

9

Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors.

Hungate RW, Chen JL, Starbuck KE, Vacca JP, McDaniel SL, Levin RB, Dorsey BD, Guare JP, Holloway MK, Whitter W, et al. Hungate RW, et al. Among authors: vacca jp. Bioorg Med Chem. 1994 Sep;2(9):859-79. doi: 10.1016/s0968-0896(00)82037-4. Bioorg Med Chem. 1994. PMID: 7712123

10

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site.

Holloway MK, Wai JM, Halgren TA, Fitzgerald PM, Vacca JP, Dorsey BD, Levin RB, Thompson WJ, Chen LJ, deSolms SJ. Holloway MK, et al. Among authors: vacca jp. J Med Chem. 1995 Jan 20;38(2):305-17. doi: 10.1021/jm00002a012. J Med Chem. 1995. PMID: 7830273

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