Lesnik EA - Search Results

1

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats.

Geary RS, Watanabe TA, Truong L, Freier S, Lesnik EA, Sioufi NB, Sasmor H, Manoharan M, Levin AA. Geary RS, et al. Among authors: lesnik ea. J Pharmacol Exp Ther. 2001 Mar;296(3):890-7. J Pharmacol Exp Ther. 2001. PMID: 11181921

2

2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.

Prakash TP, Manoharan M, Kawasaki AM, Fraser AS, Lesnik EA, Sioufi N, Leeds JM, Teplova M, Egli M. Prakash TP, et al. Among authors: lesnik ea. Biochemistry. 2002 Oct 1;41(39):11642-8. doi: 10.1021/bi020264t. Biochemistry. 2002. PMID: 12269806

3

Improving antisense oligonucleotide binding to human serum albumin: dramatic effect of ibuprofen conjugation.

Manoharan M, Inamati GB, Lesnik EA, Sioufi NB, Freier SM. Manoharan M, et al. Among authors: lesnik ea. Chembiochem. 2002 Dec 2;3(12):1257-60. doi: 10.1002/1439-7633(20021202)3:12<1257::AID-CBIC1257>3.0.CO;2-2. Chembiochem. 2002. PMID: 12465035 No abstract available.

4

2'-O-[2-(amino)-2-oxoethyl] oligonucleotides.

Prakash TP, Kawasaki AM, Lesnik EA, Owens SR, Manoharan M. Prakash TP, et al. Among authors: lesnik ea. Org Lett. 2003 Feb 20;5(4):403-6. doi: 10.1021/ol027131k. Org Lett. 2003. PMID: 12583729

5

2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides.

Griffey RH, Monia BP, Cummins LL, Freier S, Greig MJ, Guinosso CJ, Lesnik E, Manalili SM, Mohan V, Owens S, Ross BR, Sasmor H, Wancewicz E, Weiler K, Wheeler PD, Cook PD. Griffey RH, et al. J Med Chem. 1996 Dec 20;39(26):5100-9. doi: 10.1021/jm950937o. J Med Chem. 1996. PMID: 8978841

6

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

Monia BP, Lesnik EA, Gonzalez C, Lima WF, McGee D, Guinosso CJ, Kawasaki AM, Cook PD, Freier SM. Monia BP, et al. Among authors: lesnik ea. J Biol Chem. 1993 Jul 5;268(19):14514-22. J Biol Chem. 1993. PMID: 8390996 Free article.

7

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.

Kawasaki AM, Casper MD, Freier SM, Lesnik EA, Zounes MC, Cummins LL, Gonzalez C, Cook PD. Kawasaki AM, et al. Among authors: lesnik ea. J Med Chem. 1993 Apr 2;36(7):831-41. doi: 10.1021/jm00059a007. J Med Chem. 1993. PMID: 8464037

8

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo.

Monia BP, Sasmor H, Johnston JF, Freier SM, Lesnik EA, Muller M, Geiger T, Altmann KH, Moser H, Fabbro D. Monia BP, et al. Among authors: lesnik ea. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15481-4. doi: 10.1073/pnas.93.26.15481. Proc Natl Acad Sci U S A. 1996. PMID: 8986837 Free PMC article.

9

What affects the effect of 2'-alkoxy modifications? 1. Stabilization effect of 2'-methoxy substitutions in uniformly modified DNA oligonucleotides.

Lesnik EA, Freier SM. Lesnik EA, et al. Biochemistry. 1998 May 12;37(19):6991-7. doi: 10.1021/bi972995c. Biochemistry. 1998. PMID: 9578586

10

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

Prakash TP, Manoharan M, Kawasaki AM, Lesnik EA, Owens SR, Vasquez G. Prakash TP, et al. Among authors: lesnik ea. Org Lett. 2000 Dec 14;2(25):3995-8. doi: 10.1021/ol006555g. Org Lett. 2000. PMID: 11112626

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