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Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia.
Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, Legos JJ, Erhardt JA, Ohlstein EH, Hunter AJ, Harrison DC, Philpott K, Smith BR, Adams JL, Parsons AA. Barone FC, et al. Among authors: ohlstein eh. Med Res Rev. 2001 Mar;21(2):129-45. doi: 10.1002/1098-1128(200103)21:2<129::aid-med1003>3.0.co;2-h. Med Res Rev. 2001. PMID: 11223862 Review.
SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.
Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, White RF, McVey MJ, Legos JJ, Erhardt JA, Nelson AH, Ohlstein EH, Hunter AJ, Ward K, Smith BR, Adams JL, Parsons AA. Barone FC, et al. Among authors: ohlstein eh. J Pharmacol Exp Ther. 2001 Feb;296(2):312-21. J Pharmacol Exp Ther. 2001. PMID: 11160612
Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction.
Behr TM, Nerurkar SS, Nelson AH, Coatney RW, Woods TN, Sulpizio A, Chandra S, Brooks DP, Kumar S, Lee JC, Ohlstein EH, Angermann CE, Adams JL, Sisko J, Sackner-Bernstein JD, Willette RN. Behr TM, et al. Among authors: ohlstein eh. Circulation. 2001 Sep 11;104(11):1292-8. doi: 10.1161/hc3601.094275. Circulation. 2001. PMID: 11551882
Endothelin levels increase in rat focal and global ischemia.
Barone FC, Globus MY, Price WJ, White RF, Storer BL, Feuerstein GZ, Busto R, Ohlstein EH. Barone FC, et al. Among authors: ohlstein eh. J Cereb Blood Flow Metab. 1994 Mar;14(2):337-42. doi: 10.1038/jcbfm.1994.41. J Cereb Blood Flow Metab. 1994. PMID: 8113329
211 results