Nakamura N - Search Results

1

Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones.

Akahoshi F, Ashimori A, Yoshimura T, Imada T, Nakajima M, Mitsutomi N, Kuwahara S, Ohtsuka T, Fukaya C, Miyazaki M, Nakamura N. Akahoshi F, et al. Among authors: nakamura n. Bioorg Med Chem. 2001 Feb;9(2):301-15. doi: 10.1016/s0968-0896(00)00244-3. Bioorg Med Chem. 2001. PMID: 11249123

2

Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.

Eda M, Ashimori A, Akahoshi F, Yoshimura T, Inoue Y, Fukaya C, Nakajima M, Fukuyama H, Imada T, Takai S, Shiota N, Miyazaki M, Nakamura N. Eda M, et al. Among authors: nakamura n. Bioorg Med Chem Lett. 1998 Apr 21;8(8):913-8. doi: 10.1016/s0960-894x(98)00131-0. Bioorg Med Chem Lett. 1998. PMID: 9871511

3

Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.

Eda M, Ashimori A, Akahoshi F, Yoshimura T, Inoue Y, Fukaya C, Nakajima M, Fukuyama H, Imada T, Takai S, Shiota N, Miyazaki M, Nakamura N. Eda M, et al. Among authors: nakamura n. Bioorg Med Chem Lett. 1998 Apr 21;8(8):919-24. doi: 10.1016/s0960-894x(98)00132-2. Bioorg Med Chem Lett. 1998. PMID: 9871512

4

Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.

Akahoshi F, Ashimori A, Sakashita H, Yoshimura T, Imada T, Nakajima M, Mitsutomi N, Kuwahara S, Ohtsuka T, Fukaya C, Miyazaki M, Nakamura N. Akahoshi F, et al. Among authors: nakamura n. J Med Chem. 2001 Apr 12;44(8):1286-96. doi: 10.1021/jm000496v. J Med Chem. 2001. PMID: 11312927

5

Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase.

Akahoshi F, Ashimori A, Sakashita H, Yoshimura T, Eda M, Imada T, Nakajima M, Mitsutomi N, Kuwahara S, Ohtsuka T, Fukaya C, Miyazaki M, Nakamura N. Akahoshi F, et al. Among authors: nakamura n. J Med Chem. 2001 Apr 12;44(8):1297-304. doi: 10.1021/jm000497n. J Med Chem. 2001. PMID: 11312928

6

Rat mast cell protease-I enhances immunoglobulin E production by mouse B cells stimulated with interleukin-4.

Yoshikawa T, Imada T, Nakakubo H, Nakamura N, Naito K. Yoshikawa T, et al. Among authors: nakamura n. Immunology. 2001 Nov;104(3):333-40. doi: 10.1046/j.1365-2567.2001.01320.x. Immunology. 2001. PMID: 11722648 Free PMC article.

7

Novel potassium-channel openers: preparation and pharmacological evaluation of racemic and optically active N-(6-amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine derivatives.

Eda M, Takemoto T, Ono S, Okada T, Kosaka K, Gohda M, Matzno S, Nakamura N, Fukaya C. Eda M, et al. Among authors: nakamura n. J Med Chem. 1994 Jun 24;37(13):1983-90. doi: 10.1021/jm00039a011. J Med Chem. 1994. PMID: 8027980

8

Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds.

Takemoto T, Eda M, Okada T, Sakashita H, Matzno S, Gohda M, Ebisu H, Nakamura N, Fukaya C, Hihara M, et al. Takemoto T, et al. Among authors: nakamura n. J Med Chem. 1994 Jan 7;37(1):18-25. doi: 10.1021/jm00027a003. J Med Chem. 1994. PMID: 8289193

9

Synthesis and pharmacological activity of triazolo[1,5-a]triazine derivatives inhibiting eosinophilia.

Akahoshi F, Takeda S, Okada T, Kajii M, Nishimura H, Sugiura M, Inoue Y, Fukaya C, Naito Y, Imagawa T, Nakamura N. Akahoshi F, et al. Among authors: nakamura n. J Med Chem. 1998 Jul 30;41(16):2985-93. doi: 10.1021/jm970759u. J Med Chem. 1998. PMID: 9685237

10

Secretory production of recombinant human chymase as an active form in Pichia pastoris.

Nakakubo H, Fukuyama H, Nakajima M, Imada T, Uno S, Shiota N, Takai S, Miyazaki M, Nakamura N. Nakakubo H, et al. Among authors: nakamura n. Yeast. 2000 Mar 15;16(4):315-23. doi: 10.1002/1097-0061(20000315)16:4<315::AID-YEA527>3.0.CO;2-4. Yeast. 2000. PMID: 10669869

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